DegronMD - A6NC98(CCDC88B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1184D	TCGA-BF-A5ER	SKCM	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1944
p.G1184D	TCGA-D9-A1JW	SKCM	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1944
p.G1184D	DO37786	SKCM	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1944
p.G1184D	DO219454	SKCM	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1944
p.Q1183H	TCGA-CA-5797	COAD	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.1667
p.R1179W	TCGA-CG-5721	STAD	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0556
p.R1179W	DO38192	STAD	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0556
p.E467D	TCGA-EO-A22U	UCEC	TCGA	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.2222
p.E467D	DO43755	UCEC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.2222
p.E470K	TCGA-EO-A22U	UCEC	TCGA	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.3056
p.E470K	DO43755	UCEC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.3056
p.R1179Q	TCGA-EO-A22U	UCEC	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0556
p.R1179Q	DO43755	UCEC	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0556
p.R1186H	TCGA-GS-A9TQ	DLBC	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.25
p.R1186H	DO230326	COCA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.25
p.R1186H	DO219911	DLBC	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.25
p.R1195W	DO234345	ESAD	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.7523
p.R1192L	DO229018	LICA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.7316
p.V477L	DO229015	LICA	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation altering degron motif	0.5654
p.G1180C	DO229028	LICA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.0833
p.G489V	DO229025	LICA	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.0556
p.R472L	DO229026	LICA	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation altering degron motif	0.8428
p.E1197D	DO229041	LICA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation altering degron motif	0.5647
p.G484S	DO23316	LINC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.1944
p.R469Q	DO231102	LUSC	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.2778
p.R469Q	SIDM00570	Gastric Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.2778
p.R469Q	SIDM01511	Gastric Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.2778
p.P485L	DO51268	SKCM	ICGC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.1667
p.L1198M	DO229242	THCA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.3056
p.R1468G	SIDM00855	Other Sarcomas	GDSC	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation rewiring degron network	0.3056
p.R1468G	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation rewiring degron network	0.3056
p.R1468G	SIDM00032	Bladder Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation rewiring degron network	0.3056
p.E1466D	SIDM00193	Colorectal Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation rewiring degron network	0.25
p.E1466D	ACH-000991	Colon/Colorectal Cancer	CCLE	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation rewiring degron network	0.25
p.E1466D	SNU-81	large intestine	COSMIC	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation rewiring degron network	0.25
p.P482T	SIDM00871	Non-Cancerous	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.25
p.G483W	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.2222
p.G483W	ACH-000945	Lung Cancer	CCLE	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.2222
p.L1474H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation altering degron motif	0.6202
p.L1474H	ACH-000945	Lung Cancer	CCLE	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation altering degron motif	0.6202
p.L1474H	NCI-H650	lung	COSMIC	PLTPSLS	DEG_SCF_FBW7_1	1469:1475	Mutation altering degron motif	0.6202
p.R472W	SIDM00420	Bladder Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation altering degron motif	0.8634
p.G484D	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.1944
p.G484D	SIDM01611	Endometrial Carcinoma	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.1944
p.G484D	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.1944
p.R462Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.0833
p.R462Q	ACH-002222	Leukemia	CCLE	LRGLLQVLQ	DEG_APCC_DBOX_1	471:479	Mutation rewiring degron network	0.0833
p.A1201V	SIDM01729	Endometrial Carcinoma	GDSC	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222
p.A1201V	ACH-000909	Endometrial/Uterine Cancer	CCLE	LRGRLARLE	DEG_APCC_DBOX_1	1189:1197	Mutation rewiring degron network	0.2222

Kaplan plot for CCDC88B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC88B

UniProt ID: A6NC98

Entrez ID: 283234

Protein name: Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC88B in