DegronMD

Uniprot ID: A6NC98

Source protein: Coiled-coil domain-containing protein 88B

Source gene: CCDC88B

Class: DEG_SCF_FBW7_1

Location: 1469:1475

E3 ligase: FBXW7

DEGRON score: 0.9591

ASA_SCORE: 90.7429

COIL: 0.7893

CONS_SCORE: 0.319

DSS_SCORE: 0.9596

HELIX: 0.1926

FCONS_SCORE: 0.9868

RIG_SCORE: 0.6377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1468G	SIDM00855	Other Sarcomas	GDSC	PLTPSLS	DEG_SCF_FBW7_1	0.3056
p.R1468G	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	0.3056
p.R1468G	SIDM00032	Bladder Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	0.3056
p.E1466D	SIDM00193	Colorectal Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	0.25
p.E1466D	ACH-000991	Colon/Colorectal Cancer	CCLE	PLTPSLS	DEG_SCF_FBW7_1	0.25
p.E1466D	SNU-81	large_intestine	COSMIC	PLTPSLS	DEG_SCF_FBW7_1	0.25
p.L1474H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PLTPSLS	DEG_SCF_FBW7_1	0.6202
p.L1474H	ACH-000945	Lung Cancer	CCLE	PLTPSLS	DEG_SCF_FBW7_1	0.6202
p.L1474H	NCI-H650	lung	COSMIC	PLTPSLS	DEG_SCF_FBW7_1	0.6202

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NC98	Coiled-coil domain-containing protein 88B	DEG_SCF_FBW7_1	1469:1475	PLTPSLS	FBXW7	0.9591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons