DegronMD

Uniprot ID: A6NC98

Source protein: Coiled-coil domain-containing protein 88B

Source gene: CCDC88B

Class: DEG_APCC_DBOX_1

Location: 1189:1197

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8373

ASA_SCORE: 105.4667

COIL: 0.0324

CONS_SCORE: 0.598

DSS_SCORE: 0.3602

HELIX: 0.9699

FCONS_SCORE: 1.2502

RIG_SCORE: 0.7552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1184D	TCGA-BF-A5ER	SKCM	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	0.1944
p.G1184D	TCGA-D9-A1JW	SKCM	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	0.1944
p.G1184D	DO37786	SKCM	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.1944
p.G1184D	DO219454	SKCM	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.1944
p.Q1183H	TCGA-CA-5797	COAD	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	0.1667
p.R1179W	TCGA-CG-5721	STAD	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	0.0556
p.R1179W	DO38192	STAD	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.0556
p.R1179Q	TCGA-EO-A22U	UCEC	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	0.0556
p.R1179Q	DO43755	UCEC	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.0556
p.R1186H	TCGA-GS-A9TQ	DLBC	TCGA	LRGRLARLE	DEG_APCC_DBOX_1	0.25
p.R1186H	DO230326	COCA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.25
p.R1186H	DO219911	DLBC	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.25
p.R1195W	DO234345	ESAD	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.7523
p.R1192L	DO229018	LICA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.7316
p.G1180C	DO229028	LICA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.0833
p.E1197D	DO229041	LICA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.5647
p.L1198M	DO229242	THCA	ICGC	LRGRLARLE	DEG_APCC_DBOX_1	0.3056
p.A1201V	SIDM01729	Endometrial Carcinoma	GDSC	LRGRLARLE	DEG_APCC_DBOX_1	0.2222
p.A1201V	ACH-000909	Endometrial/Uterine Cancer	CCLE	LRGRLARLE	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NC98	Coiled-coil domain-containing protein 88B	DEG_APCC_DBOX_1	1189:1197	LRGRLARLE	APC,CDC20,FZR1	0.8373	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons