DegronMD

Uniprot ID: Q86YV0

Source protein: RAS protein activator like-3

Source gene: RASAL3

Class: DEG_APCC_DBOX_1

Location: 929:937

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8445

ASA_SCORE: 94.9111

COIL: 0.0679

CONS_SCORE: 0.3313

DSS_SCORE: 0.4809

HELIX: 0.9359

FCONS_SCORE: 1.0894

RIG_SCORE: 0.7557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S944R	TCGA-BR-6452	STAD	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	0.5833
p.S944R	DO38404	STAD	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	0.5833
p.S938A	TCGA-E6-A1LX	UCEC	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	0.3056
p.S938A	DO41020	UCEC	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	0.3056
p.E946G	TCGA-F5-6814	READ	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	0.0833
p.E946G	DO36556	READ	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	0.0833
p.E946Q	TCGA-FD-A6TA	BLCA	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	0.0833
p.E946Q	DO49753	BLCA	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	0.0833
p.R941G	TCGA-L5-A4OF	ESCA	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	0.2222
p.R920W	TCGA-MU-A5YI	CESC	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	0.0833
p.R920W	DO44346	CESC	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	0.0833
p.G943V	SIDM02014	Esophageal Carcinoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	0.1667
p.R939S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	0.2778
p.R939S	SIDM01432	Kidney Carcinoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	0.2778
p.T923R	SIDM00974	Melanoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	0.1667
p.T923R	SIDM00462	Acute Myeloid Leukemia	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	0.1667
p.T923R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV0	RAS protein activator like-3	DEG_APCC_DBOX_1	929:937	LRGQLQDLD	APC,CDC20,FZR1	0.8445	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons