DegronMD - Q86YV0(RASAL3)

FUNCTION: Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.

GO - Biological processes (BP): negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of NK T cell proliferation [GO:0051142]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165]

GO - Molecular function (MF): GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]

GO - Cellular component (CC): cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R202W	SIDM00534	Colorectal Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8634
p.R202W	ACH-000986	Colon/Colorectal Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8634
p.R202W	HT-115	large intestine	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8634
p.R723Q	TCGA-AR-A254	BRCA	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	DO1286	BRCA	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	SIDM00373	Endometrial Carcinoma	GDSC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	ACH-002026	Endometrial/Uterine Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	SNG-M	endometrium	COSMIC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R202Q	TCGA-LN-A8I1	ESCA	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7329
p.L205I	SIDM01146	Gastric Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7174
p.L205I	ACH-000932	Gastric Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7174
p.L205I	NCI-SNU-1	stomach	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7174
p.L232M	TCGA-43-6771	LUSC	TCGA	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.711
p.L232M	DO26443	LUSC	ICGC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.711
p.T779N	DO228948	LICA	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation altering degron motif	0.7055
p.S236F	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6871
p.S236F	ACH-000858	Lung Cancer	CCLE	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6871
p.S236F	KNS-62	lung	COSMIC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6871
p.E727V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6582

Showing 1 to 20 of 116 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASAL3

UniProt ID: Q86YV0

Entrez ID: 64926

Protein name: RAS protein activator like-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASAL3 in