DegronMD - Q86YV0(RASAL3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L232M	TCGA-43-6771	LUSC	TCGA	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.711
p.L232M	DO26443	LUSC	ICGC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.711
p.R789P	TCGA-55-7994	LUAD	TCGA	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1667
p.R789P	DO45311	LUAD	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1667
p.D774E	TCGA-56-8307	LUSC	TCGA	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.2778
p.D774E	DO219139	LUSC	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.2778
p.R734Q	TCGA-AJ-A2QO	UCEC	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.2222
p.R734Q	DO42177	UCEC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.2222
p.R723Q	TCGA-AR-A254	BRCA	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	DO1286	BRCA	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	SIDM00373	Endometrial Carcinoma	GDSC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	ACH-002026	Endometrial/Uterine Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.R723Q	SNG-M	endometrium	COSMIC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.7329
p.D719H	TCGA-AX-A2IO	UCEC	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.25
p.D719H	DO40800	UCEC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.25
p.E717K	TCGA-BH-A0EE	BRCA	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.1944
p.E717K	DO6088	BRCA	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.1944
p.S944R	TCGA-BR-6452	STAD	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation blocking phosphorylation signal	0.5833
p.S944R	DO38404	STAD	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation blocking phosphorylation signal	0.5833
p.K211N	TCGA-BS-A0UV	UCEC	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2778
p.K211N	DO42793	UCEC	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2778
p.D724E	TCGA-CA-6717	COAD	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.5647
p.D724E	DO8264	COAD	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.5647
p.T713A	TCGA-D5-6530	COAD	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.0833
p.T713A	DO8312	COAD	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.0833
p.V201I	TCGA-D5-6928	COAD	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.5965
p.V201I	DO7776	COAD	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.5965
p.V201I	ACH-002080	Neuroblastoma	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.5965
p.S938A	TCGA-E6-A1LX	UCEC	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.3056
p.S938A	DO41020	UCEC	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.3056
p.R219Q	TCGA-EA-A3Y4	CESC	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.0556
p.R219Q	TCGA-EA-A3Y4	CESC	TCGA	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0833
p.R219Q	DO222955	BTCA	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.0556
p.R219Q	DO222955	BTCA	ICGC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0833
p.R219Q	DO48998	CESC	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.0556
p.R219Q	DO48998	CESC	ICGC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0833
p.E946G	TCGA-F5-6814	READ	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.0833
p.E946G	DO36556	READ	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.0833
p.A771P	TCGA-FD-A5BR	BLCA	TCGA	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1944
p.A771P	DO44041	BLCA	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1944
p.E946Q	TCGA-FD-A6TA	BLCA	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.0833
p.E946Q	DO49753	BLCA	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.0833
p.A193S	TCGA-FP-A9TM	STAD	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.A193S	DO222332	STAD	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.G203E	TCGA-FW-A3R5	SKCM	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.6087
p.G203E	DO37406	SKCM	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.6087
p.R941G	TCGA-L5-A4OF	ESCA	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.2222
p.R202Q	TCGA-LN-A8I1	ESCA	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7329
p.R920W	TCGA-MU-A5YI	CESC	TCGA	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.0833
p.R920W	DO44346	CESC	ICGC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.0833
p.R244Q	TCGA-UF-A7JT	HNSC	TCGA	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.R244Q	DO219090	HNSC	ICGC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.E717A	DO222762	COCA	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.1944
p.T779N	DO228948	LICA	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation altering degron motif	0.7055
p.P218T	DO229022	LICA	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.0833
p.P218T	DO229022	LICA	ICGC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0556
p.D719E	DO230946	LUSC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.25
p.D719E	DO224605	LUSC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation rewiring degron network	0.25
p.E217V	DO224563	LUSC	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.R789L	DO229227	THCA	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1667
p.D774Y	SIDM02034	Colorectal Carcinoma	GDSC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.2778
p.G943V	SIDM02014	Esophageal Carcinoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.1667
p.R939S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.2778
p.R939S	SIDM01432	Kidney Carcinoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.2778
p.L240M	SIDM00142	Endometrial Carcinoma	GDSC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2222
p.L240M	ACH-000864	Endometrial/Uterine Cancer	CCLE	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2222
p.L240M	COLO-684	endometrium	COSMIC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2222
p.Q197E	SIDM00719	Small Cell Lung Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222
p.Q197E	ACH-001364	Lung Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222
p.Q197E	NCI-H345	lung	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222
p.T923R	SIDM00974	Melanoma	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.1667
p.T923R	SIDM00462	Acute Myeloid Leukemia	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.1667
p.T923R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LRGQLQDLD	DEG_APCC_DBOX_1	929:937	Mutation rewiring degron network	0.1667
p.N200D	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.3056
p.N200D	ACH-000563	Lung Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.3056
p.N200D	EBC-1	lung	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.3056
p.S236F	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6871
p.S236F	ACH-000858	Lung Cancer	CCLE	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6871
p.S236F	KNS-62	lung	COSMIC	SRESLATLS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6871
p.E727V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6582
p.E727V	ACH-000917	Esophageal Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6582
p.E727V	TE-4	oesophagus	COSMIC	TRDTLEPLP	DEG_APCC_DBOX_1	722:730	Mutation altering degron motif	0.6582
p.L205I	SIDM01146	Gastric Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7174
p.L205I	ACH-000932	Gastric Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7174
p.L205I	NCI-SNU-1	stomach	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7174
p.R773G	SIDM00032	Bladder Carcinoma	GDSC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.25
p.R773G	ACH-000839	Bladder Cancer	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.25
p.R202W	SIDM00534	Colorectal Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8634
p.R202W	ACH-000986	Colon/Colorectal Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8634
p.R202W	HT-115	large intestine	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8634
p.R215W	SIDM00079	Ovarian Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1667
p.R215W	ACH-000811	Ovarian Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1667
p.R215W	SK-OV-3	ovary	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1667
p.R793H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.0556
p.R793H	ACH-000942	Leukemia	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.0556
p.K213R	ACH-000146	Leukemia	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000200	Brain Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000247	Gastric Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000299	Leukemia	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000453	Myeloma	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000584	Ovarian Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000714	Myeloma	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000738	Brain Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-000917	Esophageal Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	ACH-001606	Brain Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	KMS-11	haematopoietic and lymphoid tissue	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	OCUM-1	stomach	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	no-11	central nervous system	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	JHOS-4	ovary	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	THP-1	haematopoietic and lymphoid tissue	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	TE-4	oesophagus	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	NMC-G1	central nervous system	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.K213R	GB-1	central nervous system	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.3333
p.R789S	ACH-000582	Skin Cancer	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1667
p.L775F	ACH-002659	Colon/Colorectal Cancer	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASAL3

UniProt ID: Q86YV0

Entrez ID: 64926

Protein name: RAS protein activator like-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASAL3 in