DegronMD

Uniprot ID: Q86YV0

Source protein: RAS protein activator like-3

Source gene: RASAL3

Class: DEG_APCC_DBOX_1

Location: 228:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9556

ASA_SCORE: 61.2111

COIL: 0.5201

CONS_SCORE: 0.3331

DSS_SCORE: 0.4716

HELIX: 0.3291

FCONS_SCORE: 0.9928

RIG_SCORE: 0.7089

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L232M	TCGA-43-6771	LUSC	TCGA	SRESLATLS	DEG_APCC_DBOX_1	0.711
p.L232M	DO26443	LUSC	ICGC	SRESLATLS	DEG_APCC_DBOX_1	0.711
p.R219Q	TCGA-EA-A3Y4	CESC	TCGA	SRESLATLS	DEG_APCC_DBOX_1	0.0833
p.R219Q	DO222955	BTCA	ICGC	SRESLATLS	DEG_APCC_DBOX_1	0.0833
p.R219Q	DO48998	CESC	ICGC	SRESLATLS	DEG_APCC_DBOX_1	0.0833
p.R244Q	TCGA-UF-A7JT	HNSC	TCGA	SRESLATLS	DEG_APCC_DBOX_1	0.1111
p.R244Q	DO219090	HNSC	ICGC	SRESLATLS	DEG_APCC_DBOX_1	0.1111
p.P218T	DO229022	LICA	ICGC	SRESLATLS	DEG_APCC_DBOX_1	0.0556
p.L240M	SIDM00142	Endometrial Carcinoma	GDSC	SRESLATLS	DEG_APCC_DBOX_1	0.2222
p.L240M	ACH-000864	Endometrial/Uterine Cancer	CCLE	SRESLATLS	DEG_APCC_DBOX_1	0.2222
p.L240M	COLO-684	endometrium	COSMIC	SRESLATLS	DEG_APCC_DBOX_1	0.2222
p.S236F	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	SRESLATLS	DEG_APCC_DBOX_1	0.6871
p.S236F	ACH-000858	Lung Cancer	CCLE	SRESLATLS	DEG_APCC_DBOX_1	0.6871
p.S236F	KNS-62	lung	COSMIC	SRESLATLS	DEG_APCC_DBOX_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV0	RAS protein activator like-3	DEG_APCC_DBOX_1	228:236	SRESLATLS	APC,CDC20,FZR1	0.9556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons