DegronMD

Uniprot ID: Q86YV0

Source protein: RAS protein activator like-3

Source gene: RASAL3

Class: DEG_APCC_DBOX_1

Location: 201:209

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8738

ASA_SCORE: 94.5111

COIL: 0.4889

CONS_SCORE: 0.3663

DSS_SCORE: 0.6254

HELIX: 0.4787

FCONS_SCORE: 1.0879

RIG_SCORE: 0.7639

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K211N	TCGA-BS-A0UV	UCEC	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	0.2778
p.K211N	DO42793	UCEC	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.2778
p.V201I	TCGA-D5-6928	COAD	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	0.5965
p.V201I	DO7776	COAD	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.5965
p.V201I	ACH-002080	Neuroblastoma	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.5965
p.R219Q	TCGA-EA-A3Y4	CESC	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	0.0556
p.R219Q	DO222955	BTCA	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.0556
p.R219Q	DO48998	CESC	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.0556
p.A193S	TCGA-FP-A9TM	STAD	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	0.1111
p.A193S	DO222332	STAD	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.1111
p.G203E	TCGA-FW-A3R5	SKCM	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	0.6087
p.G203E	DO37406	SKCM	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.6087
p.R202Q	TCGA-LN-A8I1	ESCA	TCGA	VRGLLKRLK	DEG_APCC_DBOX_1	0.7329
p.P218T	DO229022	LICA	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.0833
p.E217V	DO224563	LUSC	ICGC	VRGLLKRLK	DEG_APCC_DBOX_1	0.1111
p.Q197E	SIDM00719	Small Cell Lung Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	0.2222
p.Q197E	ACH-001364	Lung Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.2222
p.Q197E	NCI-H345	lung	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.2222
p.N200D	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3056
p.N200D	ACH-000563	Lung Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3056
p.N200D	EBC-1	lung	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3056
p.L205I	SIDM01146	Gastric Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	0.7174
p.L205I	ACH-000932	Gastric Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.7174
p.L205I	NCI-SNU-1	stomach	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.7174
p.R202W	SIDM00534	Colorectal Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	0.8634
p.R202W	ACH-000986	Colon/Colorectal Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.8634
p.R202W	HT-115	large_intestine	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.8634
p.R215W	SIDM00079	Ovarian Carcinoma	GDSC	VRGLLKRLK	DEG_APCC_DBOX_1	0.1667
p.R215W	ACH-000811	Ovarian Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.1667
p.R215W	SK-OV-3	ovary	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.1667
p.K213R	ACH-000146	Leukemia	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000200	Brain Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000247	Gastric Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000299	Leukemia	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000453	Myeloma	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000584	Ovarian Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000714	Myeloma	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000738	Brain Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-000917	Esophageal Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	ACH-001606	Brain Cancer	CCLE	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	OCUM-1	stomach	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	no-11	central_nervous_system	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	JHOS-4	ovary	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	TE-4	oesophagus	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	NMC-G1	central_nervous_system	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333
p.K213R	GB-1	central_nervous_system	COSMIC	VRGLLKRLK	DEG_APCC_DBOX_1	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRGLLKRLK

Degron related mutations and impact score

Drug responses associated with RASAL3 mutations

All proteins holding degron of VRGLLKRLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV0	RAS protein activator like-3	DEG_APCC_DBOX_1	201:209	VRGLLKRLK	APC,CDC20,FZR1	0.8738	More...