DegronMD

Uniprot ID: Q86YV0

Source protein: RAS protein activator like-3

Source gene: RASAL3

Class: DEG_SCF_FBW7_1

Location: 776:783

E3 ligase: FBXW7

DEGRON score: 0.9636

ASA_SCORE: 76.575

COIL: 0.784

CONS_SCORE: 0.2971

DSS_SCORE: 0.5993

HELIX: 0.1611

FCONS_SCORE: 0.9094

RIG_SCORE: 0.6931

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R789P	TCGA-55-7994	LUAD	TCGA	PKHTPLIS	DEG_SCF_FBW7_1	0.1667
p.R789P	DO45311	LUAD	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	0.1667
p.D774E	TCGA-56-8307	LUSC	TCGA	PKHTPLIS	DEG_SCF_FBW7_1	0.2778
p.D774E	DO219139	LUSC	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	0.2778
p.A771P	TCGA-FD-A5BR	BLCA	TCGA	PKHTPLIS	DEG_SCF_FBW7_1	0.1944
p.A771P	DO44041	BLCA	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	0.1944
p.T779N	DO228948	LICA	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	0.7055
p.R789L	DO229227	THCA	ICGC	PKHTPLIS	DEG_SCF_FBW7_1	0.1667
p.D774Y	SIDM02034	Colorectal Carcinoma	GDSC	PKHTPLIS	DEG_SCF_FBW7_1	0.2778
p.R773G	SIDM00032	Bladder Carcinoma	GDSC	PKHTPLIS	DEG_SCF_FBW7_1	0.25
p.R773G	ACH-000839	Bladder Cancer	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	0.25
p.R793H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PKHTPLIS	DEG_SCF_FBW7_1	0.0556
p.R793H	ACH-000942	Leukemia	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	0.0556
p.R789S	ACH-000582	Skin Cancer	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	0.1667
p.L775F	ACH-002659	Colon/Colorectal Cancer	CCLE	PKHTPLIS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV0	RAS protein activator like-3	DEG_SCF_FBW7_1	776:783	PKHTPLIS	FBXW7	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons