DegronMD

Uniprot ID: Q86YV0

Source protein: RAS protein activator like-3

Source gene: RASAL3

Class: DEG_APCC_DBOX_1

Location: 722:730

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8772

ASA_SCORE: 71.2667

COIL: 0.5764

CONS_SCORE: 0.5544

DSS_SCORE: 0.2897

HELIX: 0.4002

FCONS_SCORE: 1.5045

RIG_SCORE: 0.824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R734Q	TCGA-AJ-A2QO	UCEC	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	0.2222
p.R734Q	DO42177	UCEC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.2222
p.R723Q	TCGA-AR-A254	BRCA	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	0.7329
p.R723Q	DO1286	BRCA	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.7329
p.R723Q	SIDM00373	Endometrial Carcinoma	GDSC	TRDTLEPLP	DEG_APCC_DBOX_1	0.7329
p.R723Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	0.7329
p.R723Q	ACH-002026	Endometrial/Uterine Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	0.7329
p.R723Q	SNG-M	endometrium	COSMIC	TRDTLEPLP	DEG_APCC_DBOX_1	0.7329
p.D719H	TCGA-AX-A2IO	UCEC	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	0.25
p.D719H	DO40800	UCEC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.25
p.E717K	TCGA-BH-A0EE	BRCA	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	0.1944
p.E717K	DO6088	BRCA	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.1944
p.D724E	TCGA-CA-6717	COAD	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	0.5647
p.D724E	DO8264	COAD	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.5647
p.T713A	TCGA-D5-6530	COAD	TCGA	TRDTLEPLP	DEG_APCC_DBOX_1	0.0833
p.T713A	DO8312	COAD	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.0833
p.E717A	DO222762	COCA	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.1944
p.D719E	DO230946	LUSC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.25
p.D719E	DO224605	LUSC	ICGC	TRDTLEPLP	DEG_APCC_DBOX_1	0.25
p.E727V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	TRDTLEPLP	DEG_APCC_DBOX_1	0.6582
p.E727V	ACH-000917	Esophageal Cancer	CCLE	TRDTLEPLP	DEG_APCC_DBOX_1	0.6582
p.E727V	TE-4	oesophagus	COSMIC	TRDTLEPLP	DEG_APCC_DBOX_1	0.6582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV0	RAS protein activator like-3	DEG_APCC_DBOX_1	722:730	TRDTLEPLP	APC,CDC20,FZR1	0.8772	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons