DegronMD

Uniprot ID: P04141

Source protein: Granulocyte-macrophage colony-stimulating factor

Source gene: CSF2

Class: DEG_APCC_DBOX_1

Location: 83:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9365

ASA_SCORE: 68.2556

COIL: 0.4766

CONS_SCORE: 0.8095

DSS_SCORE: 0.3324

HELIX: 0.4817

FCONS_SCORE: 1.0357

RIG_SCORE: 0.741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L90F	TCGA-63-7021	LUSC	TCGA	LRGSLTKLK	DEG_APCC_DBOX_1	0.6981
p.L90F	DO26782	LUSC	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	0.6981
p.R75H	TCGA-AP-A1DO	UCEC	TCGA	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.R75H	DO43250	UCEC	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.R75H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.R75H	ACH-001737	Leukemia	CCLE	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.R75H	ACH-002222	Leukemia	CCLE	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.R75H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.G85S	TCGA-EE-A2A0	SKCM	TCGA	LRGSLTKLK	DEG_APCC_DBOX_1	0.5882
p.G85S	DO37439	SKCM	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	0.5882
p.E77D	DO229026	LICA	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	0.1667
p.R75G	DO228647	PRAD	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.S99R	DO229242	THCA	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	0.1111
p.R84W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LRGSLTKLK	DEG_APCC_DBOX_1	0.8634
p.R84W	ACH-000980	Lung Cancer	CCLE	LRGSLTKLK	DEG_APCC_DBOX_1	0.8634
p.R84W	NCI-H1155	lung	COSMIC	LRGSLTKLK	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04141	Granulocyte-macrophage colony-stimulating factor	DEG_APCC_DBOX_1	83:91	LRGSLTKLK	APC,CDC20,FZR1	0.9365	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons