DegronMD - P04141(CSF2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L90F	TCGA-63-7021	LUSC	TCGA	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.6981
p.L90F	DO26782	LUSC	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.6981
p.F120L	TCGA-77-8009	LUSC	TCGA	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1111
p.F120L	DO27200	LUSC	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1111
p.P109L	TCGA-A5-A0G1	UCEC	TCGA	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.7582
p.P109L	DO42472	UCEC	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.7582
p.R75H	TCGA-AP-A1DO	UCEC	TCGA	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.R75H	DO43250	UCEC	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.R75H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.R75H	ACH-001737	Leukemia	CCLE	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.R75H	ACH-002222	Leukemia	CCLE	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.R75H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.G85S	TCGA-EE-A2A0	SKCM	TCGA	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.5882
p.G85S	DO37439	SKCM	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.5882
p.S122N	TCGA-FW-A3R5	SKCM	TCGA	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.0556
p.S122N	DO37406	SKCM	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.0556
p.T108I	DO48374	BLCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.7078
p.I117T	DO228483	BRCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.I117T	DO230334	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.I117T	DO229010	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.I117T	DO229013	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.I117T	DO229016	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.I117T	DO229003	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.I117T	DO229005	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.I117T	DO229505	LAML	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1944
p.E77D	DO229026	LICA	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1667
p.Q103H	DO27811	MALY	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.S112F	DO222647	MELA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.7982
p.R75G	DO228647	PRAD	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.S99R	DO229242	THCA	ICGC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.S99R	DO229242	THCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1389
p.T115I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.T115I	SIDM00104	Mesothelioma	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.T115I	SIDM00475	Ovarian Carcinoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.T115I	SIDM01148	Plasma Cell Myeloma	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.T115I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.T115I	SIDM00510	Small Cell Lung Carcinoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.T115I	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.T115I	SIDM00736	Non-Cancerous	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.25
p.P109S	SIDM00284	Melanoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.6752
p.P109S	ACH-000805	Skin Cancer	CCLE	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.6752
p.P109S	COLO-679	skin	COSMIC	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.6752
p.R84W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.8634
p.R84W	ACH-000980	Lung Cancer	CCLE	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.8634
p.R84W	NCI-H1155	lung	COSMIC	LRGSLTKLK	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.8634
p.P106S	ACH-000695	Lung Cancer	CCLE	PPTPETS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.6752

Kaplan plot for CSF2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSF2

UniProt ID: P04141

Entrez ID: 1437

Protein name: Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CSF2 in