DegronMD

Uniprot ID: P04141

Source protein: Granulocyte-macrophage colony-stimulating factor

Source gene: CSF2

Class: DEG_SCF_FBW7_1

Location: 106:112

E3 ligase: FBXW7

DEGRON score: 0.8558

ASA_SCORE: 73.1571

COIL: 0.883

CONS_SCORE: 0.8864

DSS_SCORE: 0.3493

HELIX: 0.0811

FCONS_SCORE: 1.2725

RIG_SCORE: 0.7048

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F120L	TCGA-77-8009	LUSC	TCGA	PPTPETS	DEG_SCF_FBW7_1	0.1111
p.F120L	DO27200	LUSC	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1111
p.P109L	TCGA-A5-A0G1	UCEC	TCGA	PPTPETS	DEG_SCF_FBW7_1	0.7582
p.P109L	DO42472	UCEC	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.7582
p.S122N	TCGA-FW-A3R5	SKCM	TCGA	PPTPETS	DEG_SCF_FBW7_1	0.0556
p.S122N	DO37406	SKCM	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.0556
p.T108I	DO48374	BLCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.7078
p.I117T	DO228483	BRCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.I117T	DO230334	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.I117T	DO229010	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.I117T	DO229013	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.I117T	DO229016	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.I117T	DO229003	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.I117T	DO229005	COCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.I117T	DO229505	LAML	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1944
p.Q103H	DO27811	MALY	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.S112F	DO222647	MELA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.7982
p.S99R	DO229242	THCA	ICGC	PPTPETS	DEG_SCF_FBW7_1	0.1389
p.T115I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.T115I	SIDM00104	Mesothelioma	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.T115I	SIDM00475	Ovarian Carcinoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.T115I	SIDM01148	Plasma Cell Myeloma	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.T115I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.T115I	SIDM00510	Small Cell Lung Carcinoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.T115I	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.T115I	SIDM00736	Non-Cancerous	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.25
p.P109S	SIDM00284	Melanoma	GDSC	PPTPETS	DEG_SCF_FBW7_1	0.6752
p.P109S	ACH-000805	Skin Cancer	CCLE	PPTPETS	DEG_SCF_FBW7_1	0.6752
p.P109S	COLO-679	skin	COSMIC	PPTPETS	DEG_SCF_FBW7_1	0.6752
p.P106S	ACH-000695	Lung Cancer	CCLE	PPTPETS	DEG_SCF_FBW7_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPETS

Degron related mutations and impact score

Drug responses associated with CSF2 mutations

All proteins holding degron of PPTPETS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04141	Granulocyte-macrophage colony-stimulating factor	DEG_SCF_FBW7_1	106:112	PPTPETS	FBXW7	0.8558	More...