DegronMD

Uniprot ID: Q9H2S9

Source protein: Zinc finger protein Eos

Source gene: IKZF4

Class: DEG_SCF_FBW7_1

Location: 506:513

E3 ligase: FBXW7

DEGRON score: 0.9901

ASA_SCORE: 58.5

COIL: 0.7139

CONS_SCORE: 0.3637

DSS_SCORE: 0.5956

HELIX: 0.0589

FCONS_SCORE: 0.8235

RIG_SCORE: 0.6205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R518W	TCGA-43-6773	LUSC	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	0.1944
p.R507Q	TCGA-AP-A0LT	UCEC	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	0.6218
p.E497V	TCGA-BS-A0V7	UCEC	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	0.0833
p.V519A	TCGA-CG-5721	STAD	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	0.1667
p.G504W	TCGA-EB-A1NK	SKCM	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	0.2778
p.E497K	TCGA-L5-A8NL	ESCA	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	0.0833
p.G508V	DO228985	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	0.6421
p.G519C	DO229028	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	0.1667
p.C515F	DO229022	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	0.2778
p.C515F	DO229041	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	0.2778
p.M504I	DO51761	STAD	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	0.2778
p.R518Q	SIDM00216	Colorectal Carcinoma	GDSC	LRGTPGPS	DEG_SCF_FBW7_1	0.1944
p.R518Q	SNU-175	large_intestine	COSMIC	LRGTPGPS	DEG_SCF_FBW7_1	0.1944
p.L517F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LRGTPGPS	DEG_SCF_FBW7_1	0.2222
p.L517F	ACH-000981	Leukemia	CCLE	LRGTPGPS	DEG_SCF_FBW7_1	0.2222
p.L517F	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LRGTPGPS	DEG_SCF_FBW7_1	0.2222
p.G521C	SIDM00445	Esophageal Carcinoma	GDSC	LRGTPGPS	DEG_SCF_FBW7_1	0.1111
p.G521C	OACp4C	oesophagus	COSMIC	LRGTPGPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2S9	Zinc finger protein Eos	DEG_SCF_FBW7_1	506:513	LRGTPGPS	FBXW7	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons