DegronMD

Uniprot ID: Q86YS3

Source protein: Rab11 family-interacting protein 4

Source gene: RAB11FIP4

Class: DEG_APCC_DBOX_1

Location: 503:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5283

ASA_SCORE: 101.5889

COIL: 0.0416

CONS_SCORE: 0.4701

DSS_SCORE: 0.2932

HELIX: 0.9584

FCONS_SCORE: 1.2626

RIG_SCORE: 0.8202

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R504W	TCGA-BS-A0TC	UCEC	TCGA	LRKELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R504W	DO42400	UCEC	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R504W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R504W	ACH-000995	Leukemia	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R504W	ACH-001856	Bile Duct Cancer	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R504W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.8634
p.A495V	TCGA-DH-5141	LGG	TCGA	LRKELEHLQ	DEG_APCC_DBOX_1	0.1111
p.A495V	DO22221	LGG	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1111
p.D516N	TCGA-EE-A20F	SKCM	TCGA	LRKELEHLQ	DEG_APCC_DBOX_1	0.1944
p.D516N	DO37961	SKCM	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1944
p.S494L	DO448	BLCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0833
p.S494L	DO761	BLCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0833
p.S494L	DO220881	MELA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0833
p.S494L	DO219468	SKCM	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0833
p.S494L	KYAE-1	oesophagus	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0833
p.M499T	DO227749	BRCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2222
p.E497Q	DO222650	BTCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1667
p.E506D	DO229031	LICA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.5647
p.R513S	DO229031	LICA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2778
p.R504L	DO229036	LICA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.8428
p.A495S	DO229177	LMS	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1111
p.R495L	DO23592	LUAD	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1111
p.E507K	DO26846	LUSC	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.7022
p.R495C	DO52664	MALY	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1111
p.A501S	DO50682	ORCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2778
p.R493Q	DO51130	PRAD	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0556
p.R493W	SIDM01314	Colorectal Carcinoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0556
p.R493W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0556
p.R493W	ACH-000920	Leukemia	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	0.0556
p.R493W	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.0556
p.R519W	SIDM01951	Colorectal Carcinoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1111
p.E501K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2778
p.E501K	SIDM00342	T-Lymphoblastic Leukemia	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2778
p.E501K	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2778
p.E501K	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2778
p.L499R	SIDM00685	Glioblastoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2222
p.L499R	LN-18	central_nervous_system	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.2222
p.Q497R	SIDM00220	Ovarian Carcinoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1667
p.Q497R	ACH-001145	Ovarian Cancer	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	0.1667
p.Q497R	OC-314	ovary	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1667
p.L498I	NCI-H1648	lung	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRKELEHLQ

Degron related mutations and impact score

Drug responses associated with RAB11FIP4 mutations

All proteins holding degron of LRKELEHLQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YS3	Rab11 family-interacting protein 4	DEG_APCC_DBOX_1	503:511	LRKELEHLQ	APC,CDC20,FZR1	0.5283	More...