DegronMD - Q86YS3(RAB11FIP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S230R	TCGA-25-1320	OV	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.0833
p.S230R	DO31510	OV	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.0833
p.S249L	TCGA-AG-4008	READ	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.2222
p.S249L	DO36386	READ	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.2222
p.R504W	TCGA-BS-A0TC	UCEC	TCGA	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.8634
p.R504W	DO42400	UCEC	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.8634
p.R504W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.8634
p.R504W	ACH-000995	Leukemia	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.8634
p.R504W	ACH-001856	Bile Duct Cancer	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.8634
p.R504W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.8634
p.D245H	TCGA-D3-A3MR	SKCM	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation altering degron motif	0.7688
p.D245H	DO47256	SKCM	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation altering degron motif	0.7688
p.A495V	TCGA-DH-5141	LGG	TCGA	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.A495V	DO22221	LGG	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.A254V	TCGA-DU-6392	LGG	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.0833
p.A254V	DO22237	LGG	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.0833
p.D516N	TCGA-EE-A20F	SKCM	TCGA	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.D516N	DO37961	SKCM	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.T238I	TCGA-GD-A6C6	BLCA	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.3056
p.T238I	DO48504	BLCA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.3056
p.S195C	TCGA-L5-A4OX	ESCA	TCGA	LVHTPSMT	DEG_SCF_FBW7_1	190:197	Mutation altering degron motif	0.643
p.S202Y	TCGA-OR-A5JA	ACC	TCGA	LVHTPSMT	DEG_SCF_FBW7_1	190:197	Mutation rewiring degron network	0.1944
p.P234T	TCGA-OR-A5JA	ACC	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.1944
p.D235N	TCGA-VS-A952	CESC	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.2222
p.D235N	DO51636	CESC	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.2222
p.D235N	DO51480	PACA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.2222
p.S494L	DO448	BLCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0833
p.S494L	DO761	BLCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0833
p.S494L	DO220881	MELA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0833
p.S494L	DO219468	SKCM	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0833
p.S494L	KYAE-1	oesophagus	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0833
p.Y243H	DO52611	BOCA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation altering degron motif	0.6118
p.M499T	DO227749	BRCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2222
p.E497Q	DO222650	BTCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.V242I	DO233652	GACA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation altering degron motif	0.5965
p.E506D	DO229031	LICA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.5647
p.R513S	DO229031	LICA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.R504L	DO229036	LICA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.8428
p.A495S	DO229177	LMS	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.R495L	DO23592	LUAD	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.E507K	DO26846	LUSC	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.7022
p.R495C	DO52664	MALY	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.A501S	DO50682	ORCA	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.R493Q	DO51130	PRAD	ICGC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0556
p.R493W	SIDM01314	Colorectal Carcinoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0556
p.R493W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0556
p.R493W	ACH-000920	Leukemia	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0556
p.R493W	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0556
p.R519W	SIDM01951	Colorectal Carcinoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.S189T	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVHTPSMT	DEG_SCF_FBW7_1	190:197	Mutation rewiring degron network	0.3056
p.S189T	VAL	haematopoietic and lymphoid tissue	COSMIC	LVHTPSMT	DEG_SCF_FBW7_1	190:197	Mutation rewiring degron network	0.3056
p.E501K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.E501K	SIDM00342	T-Lymphoblastic Leukemia	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.E501K	BC-3	haematopoietic and lymphoid tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.E501K	LOUCY	haematopoietic and lymphoid tissue	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.L499R	SIDM00685	Glioblastoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2222
p.L499R	LN-18	central nervous system	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2222
p.Q497R	SIDM00220	Ovarian Carcinoma	GDSC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.Q497R	ACH-001145	Ovarian Cancer	CCLE	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.Q497R	OC-314	ovary	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.R188Q	BE2-M17	autonomic ganglia	COSMIC	LVHTPSMT	DEG_SCF_FBW7_1	190:197	Mutation rewiring degron network	0.2778
p.D229H	CPC-N	lung	COSMIC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	239:245	Mutation rewiring degron network	0.0556
p.L498I	NCI-H1648	lung	COSMIC	LRKELEHLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB11FIP4

UniProt ID: Q86YS3

Entrez ID: 84440

Protein name: Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB11FIP4 in