DegronMD

Uniprot ID: Q86YS3

Source protein: Rab11 family-interacting protein 4

Source gene: RAB11FIP4

Class: DEG_SCF_FBW7_1

Location: 190:197

E3 ligase: FBXW7

DEGRON score: 0.9298

ASA_SCORE: 74.2125

COIL: 0.8403

CONS_SCORE: 0.2554

DSS_SCORE: 0.5558

HELIX: 0.1053

FCONS_SCORE: 0.9474

RIG_SCORE: 0.6886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S195C	TCGA-L5-A4OX	ESCA	TCGA	LVHTPSMT	DEG_SCF_FBW7_1	0.643
p.S202Y	TCGA-OR-A5JA	ACC	TCGA	LVHTPSMT	DEG_SCF_FBW7_1	0.1944
p.S189T	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVHTPSMT	DEG_SCF_FBW7_1	0.3056
p.S189T	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	LVHTPSMT	DEG_SCF_FBW7_1	0.3056
p.R188Q	BE2-M17	autonomic_ganglia	COSMIC	LVHTPSMT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YS3	Rab11 family-interacting protein 4	DEG_SCF_FBW7_1	190:197	LVHTPSMT	FBXW7	0.9298	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons