DegronMD

Uniprot ID: Q86YS3

Source protein: Rab11 family-interacting protein 4

Source gene: RAB11FIP4

Class: LIG_APCC_ABBAyCdc20_2

Location: 239:245

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9372

ASA_SCORE: 86.8

COIL: 0.7874

CONS_SCORE: 0.296

DSS_SCORE: 0.5953

HELIX: 0.1246

FCONS_SCORE: 0.975

RIG_SCORE: 0.7302

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D245H	TCGA-D3-A3MR	SKCM	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D245H	DO47256	SKCM	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.7688
p.Y243H	DO52611	BOCA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.6118
p.V242I	DO233652	GACA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.5965
p.T238I	TCGA-GD-A6C6	BLCA	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T238I	DO48504	BLCA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S249L	TCGA-AG-4008	READ	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S249L	DO36386	READ	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D235N	TCGA-VS-A952	CESC	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D235N	DO51636	CESC	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D235N	DO51480	PACA	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P234T	TCGA-OR-A5JA	ACC	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S230R	TCGA-25-1320	OV	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S230R	DO31510	OV	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A254V	TCGA-DU-6392	LGG	TCGA	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A254V	DO22237	LGG	ICGC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D229H	CPC-N	lung	COSMIC	RTNVYSD	LIG_APCC_ABBAyCdc20_2	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YS3	Rab11 family-interacting protein 4	LIG_APCC_ABBAyCdc20_2	239:245	RTNVYSD	APC,CDC20,FZR1	0.9372	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons