DegronMD

Uniprot ID: Q9HCK0

Source protein: Zinc finger and BTB domain-containing protein 26

Source gene: ZBTB26

Class: DEG_APCC_DBOX_1

Location: 369:377

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9721

ASA_SCORE: 80.3444

COIL: 0.1704

CONS_SCORE: 0.8119

DSS_SCORE: 0.362

HELIX: 0.824

FCONS_SCORE: 1.2614

RIG_SCORE: 0.7768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M361I	TCGA-09-2044	OV	TCGA	LRKHLKQLH	DEG_APCC_DBOX_1	0.1111
p.M361I	DO28923	OV	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.1111
p.V362F	TCGA-D1-A103	UCEC	TCGA	LRKHLKQLH	DEG_APCC_DBOX_1	0.1389
p.V362F	DO42312	UCEC	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.1389
p.E387D	DO224847	BRCA	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.0556
p.E387D	DO227473	BRCA	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.0556
p.N384I	DO227549	COCA	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.1389
p.H372N	DO229027	LICA	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.6312
p.V368A	DO23108	LINC	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.3056
p.V368A	DO45041	LINC	ICGC	LRKHLKQLH	DEG_APCC_DBOX_1	0.3056
p.H377N	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	LRKHLKQLH	DEG_APCC_DBOX_1	0.6312
p.H377N	ACH-000463	Lung Cancer	CCLE	LRKHLKQLH	DEG_APCC_DBOX_1	0.6312
p.H377N	NCI-H460	lung	COSMIC	LRKHLKQLH	DEG_APCC_DBOX_1	0.6312
p.R370M	SIDM00683	Prostate Carcinoma	GDSC	LRKHLKQLH	DEG_APCC_DBOX_1	0.8632
p.R370M	LNCaP-Clone-FGC	prostate	COSMIC	LRKHLKQLH	DEG_APCC_DBOX_1	0.8632
p.E387K	SIDM00220	Ovarian Carcinoma	GDSC	LRKHLKQLH	DEG_APCC_DBOX_1	0.0556
p.E387K	ACH-000962	Ovarian Cancer	CCLE	LRKHLKQLH	DEG_APCC_DBOX_1	0.0556
p.E387K	ACH-001145	Ovarian Cancer	CCLE	LRKHLKQLH	DEG_APCC_DBOX_1	0.0556
p.E387K	OC-314	ovary	COSMIC	LRKHLKQLH	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK0	Zinc finger and BTB domain-containing protein 26	DEG_APCC_DBOX_1	369:377	LRKHLKQLH	APC,CDC20,FZR1	0.9721	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons