DegronMD

Uniprot ID: Q9UQE7

Source protein: Structural maintenance of chromosomes protein 3

Source gene: SMC3

Class: DEG_APCC_DBOX_1

Location: 836:844

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.505

ASA_SCORE: 95.4111

COIL: 0.0339

CONS_SCORE: 0.4017

DSS_SCORE: 0.3091

HELIX: 0.9666

FCONS_SCORE: 1.2668

RIG_SCORE: 0.8384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R827L	TCGA-FI-A2D5	UCEC	TCGA	LRKRLDQVE	DEG_APCC_DBOX_1	0.0833
p.R827L	DO41331	UCEC	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	0.0833
p.T830P	TCGA-FI-A2D5	UCEC	TCGA	LRKRLDQVE	DEG_APCC_DBOX_1	0.1667
p.T830P	DO41331	UCEC	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	0.1667
p.Q845H	DO228986	LICA	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	0.3056
p.R837K	DO232761	PBCA	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	0.7237
p.E834Q	SIDM00796	Head and Neck Carcinoma	GDSC	LRKRLDQVE	DEG_APCC_DBOX_1	0.2778
p.E834Q	ACH-000740	Head and Neck Cancer	CCLE	LRKRLDQVE	DEG_APCC_DBOX_1	0.2778
p.E834Q	A253	salivary_gland	COSMIC	LRKRLDQVE	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQE7	Structural maintenance of chromosomes protein 3	DEG_APCC_DBOX_1	836:844	LRKRLDQVE	APC,CDC20,FZR1	0.505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons