DegronMD - Q9UQE7(SMC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q230E	TCGA-06-0645	GBM	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1944
p.Q230E	DO13881	GBM	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1944
p.R236H	TCGA-A5-A0G2	UCEC	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.8244
p.R236H	DO41235	UCEC	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.8244
p.S243Y	TCGA-A5-A0G2	UCEC	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.712
p.S243Y	DO41235	UCEC	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.712
p.T235I	TCGA-AX-A06F	UCEC	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5966
p.T235I	DO41752	UCEC	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5966
p.S243C	TCGA-E5-A4U1	BLCA	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7541
p.S243C	DO44061	BLCA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7541
p.F1093C	TCGA-F5-6814	READ	TCGA	SGSQSSVPSV	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.25
p.F1093C	DO36556	READ	ICGC	SGSQSSVPSV	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.25
p.R827L	TCGA-FI-A2D5	UCEC	TCGA	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.0833
p.R827L	DO41331	UCEC	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.0833
p.T830P	TCGA-FI-A2D5	UCEC	TCGA	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.1667
p.T830P	DO41331	UCEC	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.1667
p.S1089L	DO222617	BTCA	ICGC	SGSQSSVPSV	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.7667
p.Q845H	DO228986	LICA	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.3056
p.R236L	DO229019	LICA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.8428
p.R236L	DO229029	LICA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.8428
p.SE1077RK	DO222837	MELA	ICGC	SGSQSSVPSV	DEG_COP1_1	1081:1090	Mutation blocking phosphorylation signal	0.4444
p.E247G	DO35216	PACA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2222
p.R837K	DO232761	PBCA	ICGC	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation altering degron motif	0.7237
p.T1094I	SIDM01261	Breast Carcinoma	GDSC	SGSQSSVPSV	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.T1094I	ACH-002208	Breast Cancer	CCLE	SGSQSSVPSV	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.T1094I	YMB-1-E	breast	COSMIC	SGSQSSVPSV	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.E834Q	SIDM00796	Head and Neck Carcinoma	GDSC	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.2778
p.E834Q	ACH-000740	Head and Neck Cancer	CCLE	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.2778
p.E834Q	A253	salivary gland	COSMIC	LRKRLDQVE	DEG_APCC_DBOX_1	836:844	Mutation rewiring degron network	0.2778

Kaplan plot for SMC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMC3

UniProt ID: Q9UQE7

Entrez ID: 9126

Protein name: Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMC3 in