DegronMD

Uniprot ID: Q9UQE7

Source protein: Structural maintenance of chromosomes protein 3

Source gene: SMC3

Class: DEG_APCC_DBOX_1

Location: 235:243

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8099

ASA_SCORE: 74.3333

COIL: 0.0216

CONS_SCORE: 0.336

DSS_SCORE: 0.4705

HELIX: 0.9789

FCONS_SCORE: 1.0332

RIG_SCORE: 0.7653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q230E	TCGA-06-0645	GBM	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	0.1944
p.Q230E	DO13881	GBM	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.1944
p.R236H	TCGA-A5-A0G2	UCEC	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	0.8244
p.R236H	DO41235	UCEC	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.8244
p.S243Y	TCGA-A5-A0G2	UCEC	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	0.712
p.S243Y	DO41235	UCEC	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.712
p.T235I	TCGA-AX-A06F	UCEC	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	0.5966
p.T235I	DO41752	UCEC	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.5966
p.S243C	TCGA-E5-A4U1	BLCA	TCGA	TRAKLDELS	DEG_APCC_DBOX_1	0.7541
p.S243C	DO44061	BLCA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.7541
p.R236L	DO229019	LICA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.8428
p.R236L	DO229029	LICA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.8428
p.E247G	DO35216	PACA	ICGC	TRAKLDELS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQE7	Structural maintenance of chromosomes protein 3	DEG_APCC_DBOX_1	235:243	TRAKLDELS	APC,CDC20,FZR1	0.8099	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons