DegronMD

Uniprot ID: Q9UQE7

Source protein: Structural maintenance of chromosomes protein 3

Source gene: SMC3

Class: DEG_COP1_1

Location: 1081:1090

E3 ligase: COP1

DEGRON score: 0.7823

ASA_SCORE: 67.56

COIL: 0.8523

CONS_SCORE: 0.2197

DSS_SCORE: 0.6962

HELIX: 0.0902

FCONS_SCORE: 0.5518

RIG_SCORE: 0.5724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1093C	TCGA-F5-6814	READ	TCGA	SGSQSSVPSV	DEG_COP1_1	0.25
p.F1093C	DO36556	READ	ICGC	SGSQSSVPSV	DEG_COP1_1	0.25
p.S1089L	DO222617	BTCA	ICGC	SGSQSSVPSV	DEG_COP1_1	0.7667
p.SE1077RK	DO222837	MELA	ICGC	SGSQSSVPSV	DEG_COP1_1	0.4444
p.T1094I	SIDM01261	Breast Carcinoma	GDSC	SGSQSSVPSV	DEG_COP1_1	0.2222
p.T1094I	ACH-002208	Breast Cancer	CCLE	SGSQSSVPSV	DEG_COP1_1	0.2222
p.T1094I	YMB-1-E	breast	COSMIC	SGSQSSVPSV	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQE7	Structural maintenance of chromosomes protein 3	DEG_COP1_1	1081:1090	SGSQSSVPSV	COP1	0.7823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons