DegronMD

Uniprot ID: Q6H9L7

Source protein: Isthmin-2

Source gene: ISM2

Class: DEG_APCC_DBOX_1

Location: 105:113

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6822

ASA_SCORE: 75.3222

COIL: 0.4719

CONS_SCORE: 0.2876

DSS_SCORE: 0.6589

HELIX: 0.4766

FCONS_SCORE: 1.0075

RIG_SCORE: 0.7704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P104L	TCGA-2W-A8YY	CESC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	0.3056
p.P104L	DO223732	CESC	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.3056
p.L120F	TCGA-58-8393	LUSC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	0.1389
p.L120F	DO45498	LUSC	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.1389
p.L105V	TCGA-D5-6534	COAD	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	0.5654
p.L105V	DO10718	COAD	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.5654
p.R106Q	TCGA-DM-A1D8	COAD	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	0.7329
p.R106Q	DO8914	COAD	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.7329
p.R106Q	SIDM01245	T-Lymphoblastic Leukemia	GDSC	LRLELQKLP	DEG_APCC_DBOX_1	0.7329
p.R106Q	ACH-002216	Leukemia	CCLE	LRLELQKLP	DEG_APCC_DBOX_1	0.7329
p.R106Q	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	LRLELQKLP	DEG_APCC_DBOX_1	0.7329
p.K111T	TCGA-E6-A1LX	UCEC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	0.6195
p.K111T	DO41020	UCEC	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.6195
p.A116V	TCGA-OR-A5J4	ACC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	0.25
p.R106W	DO230343	COCA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.8634
p.P113L	DO228473	GACA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.6471
p.A116D	DO229019	LICA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.25
p.G114E	DO220913	MELA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	0.3056
p.T118I	SIDM01619	Endometrial Carcinoma	GDSC	LRLELQKLP	DEG_APCC_DBOX_1	0.1944
p.T118I	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRLELQKLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6H9L7	Isthmin-2	DEG_APCC_DBOX_1	105:113	LRLELQKLP	APC,CDC20,FZR1	0.6822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons