DegronMD - Q6H9L7(ISM2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P104L	TCGA-2W-A8YY	CESC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.3056
p.P104L	TCGA-2W-A8YY	CESC	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation rewiring degron network	0.3056
p.P104L	DO223732	CESC	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.3056
p.P104L	DO223732	CESC	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation rewiring degron network	0.3056
p.L120F	TCGA-58-8393	LUSC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.1389
p.L120F	DO45498	LUSC	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.1389
p.P96T	TCGA-64-5815	LUAD	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.7031
p.P96T	DO23578	LUAD	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.7031
p.R98M	TCGA-86-A4JF	LUAD	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.7521
p.R98M	DO45317	LUAD	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.7521
p.V102A	TCGA-CG-5721	STAD	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.5825
p.V102A	DO38192	STAD	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.5825
p.L105V	TCGA-D5-6534	COAD	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.5654
p.L105V	DO10718	COAD	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.5654
p.R106Q	TCGA-DM-A1D8	COAD	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.7329
p.R106Q	DO8914	COAD	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.7329
p.R106Q	SIDM01245	T-Lymphoblastic Leukemia	GDSC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.7329
p.R106Q	ACH-002216	Leukemia	CCLE	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.7329
p.R106Q	BE-13	haematopoietic and lymphoid tissue	COSMIC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.7329
p.K111T	TCGA-E6-A1LX	UCEC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.6195
p.K111T	DO41020	UCEC	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.6195
p.A116V	TCGA-OR-A5J4	ACC	TCGA	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.25
p.R106W	DO230343	COCA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.8634
p.A94T	DO229010	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation rewiring degron network	0.2778
p.A94T	DO229013	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation rewiring degron network	0.2778
p.A94T	DO229016	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation rewiring degron network	0.2778
p.A94T	DO229003	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation rewiring degron network	0.2778
p.A94T	DO229005	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation rewiring degron network	0.2778
p.P113L	DO228473	GACA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation altering degron motif	0.6471
p.A116D	DO229019	LICA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.25
p.T99A	DO50858	LICA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.7139
p.G114E	DO220913	MELA	ICGC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.3056
p.T99I	SIDM00570	Gastric Carcinoma	GDSC	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.7078
p.T99I	ACH-000674	Gastric Cancer	CCLE	PPRTPEVT	DEG_SCF_FBW7_1	96:103	Mutation altering degron motif	0.7078
p.T118I	SIDM01619	Endometrial Carcinoma	GDSC	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.1944
p.T118I	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRLELQKLP	DEG_APCC_DBOX_1	105:113	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ISM2

UniProt ID: Q6H9L7

Entrez ID: 145501

Protein name: Isthmin-2 (Thrombospondin and AMOP domain-containing isthmin-like protein 1) (Thrombospondin type-1 domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ISM2 in