DegronMD

Uniprot ID: Q6H9L7

Source protein: Isthmin-2

Source gene: ISM2

Class: DEG_SCF_FBW7_1

Location: 96:103

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 79.825

COIL: 0.8716

CONS_SCORE: 0.3647

DSS_SCORE: 0.7152

HELIX: 0.0986

FCONS_SCORE: 1.4223

RIG_SCORE: 0.6962

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P104L	TCGA-2W-A8YY	CESC	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	0.3056
p.P104L	DO223732	CESC	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.3056
p.P96T	TCGA-64-5815	LUAD	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	0.7031
p.P96T	DO23578	LUAD	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.7031
p.R98M	TCGA-86-A4JF	LUAD	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	0.7521
p.R98M	DO45317	LUAD	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.7521
p.V102A	TCGA-CG-5721	STAD	TCGA	PPRTPEVT	DEG_SCF_FBW7_1	0.5825
p.V102A	DO38192	STAD	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.5825
p.A94T	DO229010	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.2778
p.A94T	DO229013	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.2778
p.A94T	DO229016	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.2778
p.A94T	DO229003	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.2778
p.A94T	DO229005	COCA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.2778
p.T99A	DO50858	LICA	ICGC	PPRTPEVT	DEG_SCF_FBW7_1	0.7139
p.T99I	SIDM00570	Gastric Carcinoma	GDSC	PPRTPEVT	DEG_SCF_FBW7_1	0.7078
p.T99I	ACH-000674	Gastric Cancer	CCLE	PPRTPEVT	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6H9L7	Isthmin-2	DEG_SCF_FBW7_1	96:103	PPRTPEVT	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons