DegronMD

Uniprot ID: P12644

Source protein: Bone morphogenetic protein 4

Source gene: BMP4

Class: LIG_APCC_ABBA_1

Location: 158:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6225

ASA_SCORE: 27.8667

COIL: 0.0988

CONS_SCORE: 0.632

DSS_SCORE: 0.2828

HELIX: 0.0112

FCONS_SCORE: 1.34

RIG_SCORE: 0.8395

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R162W	TCGA-2W-A8YY	CESC	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.7523
p.R162W	DO223732	CESC	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.7523
p.S155A	TCGA-39-5022	LUSC	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.25
p.S155A	DO27604	LUSC	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.25
p.D166Y	TCGA-56-8504	LUSC	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.25
p.D166Y	DO45437	LUSC	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.25
p.Q164H	TCGA-56-8629	LUSC	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.3056
p.Q164H	DO45451	LUSC	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.3056
p.G168D	TCGA-DI-A1BU	UCEC	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.1944
p.G168D	DO42023	UCEC	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1944
p.R159Q	TCGA-EO-A22T	UCEC	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.6218
p.R159Q	DO42320	UCEC	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.6218
p.S155Y	TCGA-GN-A265	SKCM	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.25
p.S155Y	DO37491	SKCM	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.25
p.E151K	TCGA-GN-A4U4	SKCM	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.1389
p.E151K	DO51256	SKCM	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1389
p.S155C	TCGA-IR-A3LL	CESC	TCGA	LRLFRE	LIG_APCC_ABBA_1	0.25
p.S155C	DO44362	CESC	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.25
p.V152A	DO228483	BRCA	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1667
p.V152A	DO230334	COCA	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1667
p.V152A	DO229013	COCA	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1667
p.V152A	DO229003	COCA	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1667
p.V152A	DO229505	LAML	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1667
p.V152A	DO228947	LICA	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1667
p.I153T	DO229211	THCA	ICGC	LRLFRE	LIG_APCC_ABBA_1	0.1944
p.E149Q	SIDM01048	Plasma Cell Myeloma	GDSC	LRLFRE	LIG_APCC_ABBA_1	0.0833
p.E149Q	ACH-000821	Myeloma	CCLE	LRLFRE	LIG_APCC_ABBA_1	0.0833
p.E149Q	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LRLFRE	LIG_APCC_ABBA_1	0.0833
p.E172K	SIDM00411	Pancreatic Carcinoma	GDSC	LRLFRE	LIG_APCC_ABBA_1	0.0833
p.E172K	ACH-000332	Pancreatic Cancer	CCLE	LRLFRE	LIG_APCC_ABBA_1	0.0833
p.E172K	YAPC	pancreas	COSMIC	LRLFRE	LIG_APCC_ABBA_1	0.0833
p.S154F	SIDM00142	Endometrial Carcinoma	GDSC	LRLFRE	LIG_APCC_ABBA_1	0.2222
p.S154F	ACH-000864	Endometrial/Uterine Cancer	CCLE	LRLFRE	LIG_APCC_ABBA_1	0.2222
p.S154F	ACH-001283	Bone Cancer	CCLE	LRLFRE	LIG_APCC_ABBA_1	0.2222
p.S154F	COLO-684	endometrium	COSMIC	LRLFRE	LIG_APCC_ABBA_1	0.2222
p.R162Q	SIDM01445	Gastric Carcinoma	GDSC	LRLFRE	LIG_APCC_ABBA_1	0.6218
p.V165L	ACH-000435	Endometrial/Uterine Cancer	CCLE	LRLFRE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRLFRE

Degron related mutations and impact score

Drug responses associated with BMP4 mutations

All proteins holding degron of LRLFRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12644	Bone morphogenetic protein 4	LIG_APCC_ABBA_1	158:163	LRLFRE	APC,CDC20,FZR1	0.6225	More...