DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRLGLSRLA
Uniprot ID:
Q96B01
Source protein:
RAD51-associated protein 1
Source gene:
RAD51AP1
Class:
DEG_APCC_DBOX_1
Location:
332:340
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9656
ASA_SCORE:
51.8
COIL:
0.4354
CONS_SCORE:
0.9803
DSS_SCORE:
0.4445
HELIX:
0.1727
FCONS_SCORE:
1.2521
RIG_SCORE:
0.7557
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L336M
TCGA-B8-4151
KIRC
TCGA
LRLGLSRLA
DEG_APCC_DBOX_1
0.711
p.L336M
DO19400
KIRC
ICGC
LRLGLSRLA
DEG_APCC_DBOX_1
0.711
p.R333C
TCGA-CR-7395
HNSC
TCGA
LRLGLSRLA
DEG_APCC_DBOX_1
0.8301
p.N348D
TCGA-FF-8047
DLBC
TCGA
LRLGLSRLA
DEG_APCC_DBOX_1
0.1111
p.N348D
DO222304
DLBC
ICGC
LRLGLSRLA
DEG_APCC_DBOX_1
0.1111
p.P327R
DO222954
BTCA
ICGC
LRLGLSRLA
DEG_APCC_DBOX_1
0.6389
p.S327F
DO222798
COCA
ICGC
LRLGLSRLA
DEG_APCC_DBOX_1
0.6389
p.T333S
DO35242
PACA
ICGC
LRLGLSRLA
DEG_APCC_DBOX_1
0.7116
p.A349V
SIDM02015
Colorectal Carcinoma
GDSC
LRLGLSRLA
DEG_APCC_DBOX_1
0.0833
p.S334N
ACH-002262
Leukemia
CCLE
LRLGLSRLA
DEG_APCC_DBOX_1
0.7069
p.S334N
KY821
haematopoietic_and_lymphoid_tissue
COSMIC
LRLGLSRLA
DEG_APCC_DBOX_1
0.7069
p.P344T
OVCA420
ovary
COSMIC
LRLGLSRLA
DEG_APCC_DBOX_1
0.2222
p.P327T
OVCA420
ovary
COSMIC
LRLGLSRLA
DEG_APCC_DBOX_1
0.6389
Drug responses associated with RAD51AP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRLGLSRLA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96B01
RAD51-associated protein 1
DEG_APCC_DBOX_1
332:340
LRLGLSRLA
APC,CDC20,FZR1
0.9656
More...