DegronMD - Q96B01(RAD51AP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E59K	TCGA-93-8067	LUAD	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.25
p.E59K	DO25113	LUAD	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.25
p.L55V	TCGA-A8-A08R	BRCA	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.1389
p.L55V	DO1255	BRCA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.1389
p.L336M	TCGA-B8-4151	KIRC	TCGA	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation altering degron motif	0.711
p.L336M	DO19400	KIRC	ICGC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation altering degron motif	0.711
p.L52V	TCGA-BS-A0UF	UCEC	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.0556
p.L52V	DO41488	UCEC	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.0556
p.R333C	TCGA-CR-7395	HNSC	TCGA	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation altering degron motif	0.8301
p.E73K	TCGA-CV-A463	HNSC	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.2222
p.E73K	DO52066	HNSC	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.2222
p.P67T	TCGA-EE-A2MM	SKCM	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.7031
p.P67T	DO37770	SKCM	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.7031
p.N348D	TCGA-FF-8047	DLBC	TCGA	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation rewiring degron network	0.1111
p.N348D	DO222304	DLBC	ICGC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation rewiring degron network	0.1111
p.P327R	DO222954	BTCA	ICGC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation blocking phosphorylation signal	0.6389
p.S327F	DO222798	COCA	ICGC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation blocking phosphorylation signal	0.6389
p.L52F	DO229009	LICA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.0556
p.P61S	DO220875	MELA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation rewiring degron network	0.3056
p.T333S	DO35242	PACA	ICGC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation altering degron motif	0.7116
p.K69E	DO229248	THCA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.7022
p.A349V	SIDM02015	Colorectal Carcinoma	GDSC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation rewiring degron network	0.0833
p.K68Q	SIDM00969	Ovarian Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.5833
p.K68Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.5833
p.K68Q	SIDM01126	Small Cell Lung Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.5833
p.K68Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.5833
p.K68Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.5833
p.K68I	SIDM00500	Colorectal Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	62:69	Mutation altering degron motif	0.642
p.S334N	ACH-002262	Leukemia	CCLE	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation altering degron motif	0.7069
p.S334N	KY821	haematopoietic and lymphoid tissue	COSMIC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation altering degron motif	0.7069
p.P344T	OVCA420	ovary	COSMIC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation rewiring degron network	0.2222
p.P327T	OVCA420	ovary	COSMIC	LRLGLSRLA	DEG_APCC_DBOX_1	332:340	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for RAD51AP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD51AP1

UniProt ID: Q96B01

Entrez ID: 10635

Protein name: RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAD51AP1 in