DegronMD

Uniprot ID: Q96B01

Source protein: RAD51-associated protein 1

Source gene: RAD51AP1

Class: DEG_SCF_SKP2-CKS1_1

Location: 62:69

E3 ligase: SKP2,CSK1

DEGRON score: 0.9879

ASA_SCORE: 118.1125

COIL: 0.8619

CONS_SCORE: 0.5785

DSS_SCORE: 0.6019

HELIX: 0.1006

FCONS_SCORE: 1.2162

RIG_SCORE: 0.7001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E59K	TCGA-93-8067	LUAD	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.E59K	DO25113	LUAD	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.L55V	TCGA-A8-A08R	BRCA	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.1389
p.L55V	DO1255	BRCA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.1389
p.L52V	TCGA-BS-A0UF	UCEC	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.0556
p.L52V	DO41488	UCEC	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E73K	TCGA-CV-A463	HNSC	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E73K	DO52066	HNSC	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P67T	TCGA-EE-A2MM	SKCM	TCGA	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P67T	DO37770	SKCM	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.7031
p.L52F	DO229009	LICA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P61S	DO220875	MELA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.K69E	DO229248	THCA	ICGC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K68Q	SIDM00969	Ovarian Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.5833
p.K68Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.5833
p.K68Q	SIDM01126	Small Cell Lung Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.5833
p.K68Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.5833
p.K68Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.5833
p.K68I	SIDM00500	Colorectal Carcinoma	GDSC	VQEKTPKK	DEG_SCF_SKP2-CKS1_1	0.642

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96B01	RAD51-associated protein 1	DEG_SCF_SKP2-CKS1_1	62:69	VQEKTPKK	SKP2,CSK1	0.9879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons