DegronMD

Uniprot ID: Q8IWB6

Source protein: Inactive serine/threonine-protein kinase TEX14

Source gene: TEX14

Class: LIG_APCC_ABBA_1

Location: 115:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9482

ASA_SCORE: 78.8167

COIL: 0.776

CONS_SCORE: 0.9037

DSS_SCORE: 0.4464

HELIX: 0.0875

FCONS_SCORE: 1.1859

RIG_SCORE: 0.7566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D119N	TCGA-AJ-A3BH	UCEC	TCGA	LRLHDE	LIG_APCC_ABBA_1	0.5821
p.D119N	DO41638	UCEC	ICGC	LRLHDE	LIG_APCC_ABBA_1	0.5821
p.D119N	SIDM00529	Breast Carcinoma	GDSC	LRLHDE	LIG_APCC_ABBA_1	0.5821
p.D119N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LRLHDE	LIG_APCC_ABBA_1	0.5821
p.P125Q	TCGA-D3-A2JB	SKCM	TCGA	LRLHDE	LIG_APCC_ABBA_1	0.1944
p.P125Q	DO47607	SKCM	ICGC	LRLHDE	LIG_APCC_ABBA_1	0.1944
p.N124K	TCGA-G3-A5SM	LIHC	TCGA	LRLHDE	LIG_APCC_ABBA_1	0.2222
p.N124K	DO44998	LIHC	ICGC	LRLHDE	LIG_APCC_ABBA_1	0.2222
p.R116Q	TCGA-KK-A8IM	PRAD	TCGA	LRLHDE	LIG_APCC_ABBA_1	0.6218
p.R116Q	DO219341	PRAD	ICGC	LRLHDE	LIG_APCC_ABBA_1	0.6218
p.L115R	TCGA-VQ-A8PX	STAD	TCGA	LRLHDE	LIG_APCC_ABBA_1	0.8428
p.L115R	DO51778	STAD	ICGC	LRLHDE	LIG_APCC_ABBA_1	0.8428
p.S106R	DO229041	LICA	ICGC	LRLHDE	LIG_APCC_ABBA_1	0.0833
p.P125L	DO35442	PACA	ICGC	LRLHDE	LIG_APCC_ABBA_1	0.1944
p.D114N	SIDM00655	Other Solid Cancers	GDSC	LRLHDE	LIG_APCC_ABBA_1	0.3056
p.D114N	ACH-001578	Embryonal Cancer	CCLE	LRLHDE	LIG_APCC_ABBA_1	0.3056
p.D114N	NCCIT	testis	COSMIC	LRLHDE	LIG_APCC_ABBA_1	0.3056
p.A111T	SIDM01617	Endometrial Carcinoma	GDSC	LRLHDE	LIG_APCC_ABBA_1	0.2222
p.A111T	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRLHDE	LIG_APCC_ABBA_1	0.2222
p.H118Q	ACH-000868	Lung Cancer	CCLE	LRLHDE	LIG_APCC_ABBA_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWB6	Inactive serine/threonine-protein kinase TEX14	LIG_APCC_ABBA_1	115:120	LRLHDE	APC,CDC20,FZR1	0.9482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons