DegronMD - Q8IWB6(TEX14)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1093F	TCGA-17-Z056	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.2222
p.E1089Q	TCGA-2L-AAQE	PAAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6744
p.E1082K	TCGA-86-A4JF	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.2778
p.D1078N	TCGA-86-A4JF	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1667
p.S1076T	TCGA-86-A4JF	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1111
p.S567R	TCGA-AA-3715	COAD	TCGA	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.0833
p.D119N	TCGA-AJ-A3BH	UCEC	TCGA	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.5821
p.D119N	DO41638	UCEC	ICGC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.5821
p.D119N	SIDM00529	Breast Carcinoma	GDSC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.5821
p.D119N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.5821
p.S1094L	TCGA-AP-A0LM	UCEC	TCGA	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1944
p.S1094L	DO43306	UCEC	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1944
p.E558K	TCGA-D3-A1Q6	SKCM	TCGA	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation altering degron motif	0.7022
p.P125Q	TCGA-D3-A2JB	SKCM	TCGA	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.1944
p.P125Q	DO47607	SKCM	ICGC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.1944
p.E1098K	TCGA-EB-A85J	SKCM	TCGA	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.0833
p.N124K	TCGA-G3-A5SM	LIHC	TCGA	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.2222
p.N124K	DO44998	LIHC	ICGC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.2222
p.R116Q	TCGA-KK-A8IM	PRAD	TCGA	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.6218
p.R116Q	DO219341	PRAD	ICGC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.6218
p.I560T	TCGA-MB-A5Y8	SARC	TCGA	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.2778
p.L115R	TCGA-VQ-A8PX	STAD	TCGA	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.8428
p.L115R	DO51778	STAD	ICGC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.8428
p.S561R	DO8018	COAD	ICGC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.25
p.G1088D	DO229010	COCA	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6087
p.G1088D	DO229013	COCA	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6087
p.G1088D	DO230659	LAML	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6087
p.G1088D	DO231140	LAML	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6087
p.G1088S	DO234220	ESAD	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.5882
p.G1088S	DO233030	GACA	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.5882
p.A1094V	DO233764	GACA	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1944
p.S1075F	DO11854	GBM	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.0833
p.T548K	DO228985	LICA	ICGC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.25
p.S106R	DO229041	LICA	ICGC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.0833
p.E1076K	DO45317	LUAD	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1111
p.P1080T	DO52667	MALY	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.2222
p.E1083Q	DO51675	PAAD	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.3056
p.P125L	DO35442	PACA	ICGC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.1944
p.I554T	DO220204	SARC	ICGC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation altering degron motif	0.7078
p.P566Q	DO37571	SKCM	ICGC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.1111
p.E552K	DO37450	SKCM	ICGC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation altering degron motif	0.7022
p.E1092K	DO50297	SKCM	ICGC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.25
p.L562P	SIDM00948	Burkitt's Lymphoma	GDSC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.2222
p.L562P	DG-75	haematopoietic and lymphoid tissue	COSMIC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.2222
p.T1095I	SIDM01019	Acute Myeloid Leukemia	GDSC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1667
p.T1095I	ACH-002258	Leukemia	CCLE	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1667
p.T1095I	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.1667
p.D1087H	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6577
p.D1087H	ACH-000951	Lung Cancer	CCLE	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6577
p.D1087H	NCI-H2342	lung	COSMIC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.6577
p.D114N	SIDM00655	Other Solid Cancers	GDSC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.D114N	ACH-001578	Embryonal Cancer	CCLE	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.D114N	NCCIT	testis	COSMIC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.A111T	SIDM01617	Endometrial Carcinoma	GDSC	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.2222
p.A111T	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.2222
p.H118Q	ACH-000868	Lung Cancer	CCLE	LRLHDE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.7582
p.G1080A	CAL-85-1	breast	COSMIC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.2222
p.T1089I	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation altering degron motif	0.7078
p.L556P	DG-75	haematopoietic and lymphoid tissue	COSMIC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation altering degron motif	0.7582
p.D1081H	NCI-H2342	lung	COSMIC	LTPDGE	DEG_SCF_FBW7_2	1084:1089	Mutation rewiring degron network	0.25
p.H564Y	NCI-H838	lung	COSMIC	PRETPDME	DEG_SCF_FBW7_2	551:558	Mutation rewiring degron network	0.1667

Kaplan plot for TEX14 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TEX14

UniProt ID: Q8IWB6

Entrez ID: 56155

Protein name: Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TEX14 in