DegronMD

Uniprot ID: Q8IWB6

Source protein: Inactive serine/threonine-protein kinase TEX14

Source gene: TEX14

Class: DEG_SCF_FBW7_2

Location: 551:558

E3 ligase: FBXW7

DEGRON score: 0.8915

ASA_SCORE: 101.7375

COIL: 0.7776

CONS_SCORE: 0.4799

DSS_SCORE: 0.58

HELIX: 0.1493

FCONS_SCORE: 0.8709

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S567R	TCGA-AA-3715	COAD	TCGA	PRETPDME	DEG_SCF_FBW7_2	0.0833
p.E558K	TCGA-D3-A1Q6	SKCM	TCGA	PRETPDME	DEG_SCF_FBW7_2	0.7022
p.I560T	TCGA-MB-A5Y8	SARC	TCGA	PRETPDME	DEG_SCF_FBW7_2	0.2778
p.S561R	DO8018	COAD	ICGC	PRETPDME	DEG_SCF_FBW7_2	0.25
p.T548K	DO228985	LICA	ICGC	PRETPDME	DEG_SCF_FBW7_2	0.25
p.I554T	DO220204	SARC	ICGC	PRETPDME	DEG_SCF_FBW7_2	0.7078
p.P566Q	DO37571	SKCM	ICGC	PRETPDME	DEG_SCF_FBW7_2	0.1111
p.E552K	DO37450	SKCM	ICGC	PRETPDME	DEG_SCF_FBW7_2	0.7022
p.L562P	SIDM00948	Burkitt's Lymphoma	GDSC	PRETPDME	DEG_SCF_FBW7_2	0.2222
p.L562P	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PRETPDME	DEG_SCF_FBW7_2	0.2222
p.L556P	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PRETPDME	DEG_SCF_FBW7_2	0.7582
p.H564Y	NCI-H838	lung	COSMIC	PRETPDME	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWB6	Inactive serine/threonine-protein kinase TEX14	DEG_SCF_FBW7_2	551:558	PRETPDME	FBXW7	0.8915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons