DegronMD

Uniprot ID: Q8IWB6

Source protein: Inactive serine/threonine-protein kinase TEX14

Source gene: TEX14

Class: DEG_SCF_FBW7_2

Location: 1084:1089

E3 ligase: FBXW7

DEGRON score: 0.9686

ASA_SCORE: 69.4333

COIL: 0.751

CONS_SCORE: 0.3189

DSS_SCORE: 0.5372

HELIX: 0.0723

FCONS_SCORE: 1.1683

RIG_SCORE: 0.7453

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1093F	TCGA-17-Z056	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	0.2222
p.E1089Q	TCGA-2L-AAQE	PAAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	0.6744
p.E1082K	TCGA-86-A4JF	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	0.2778
p.D1078N	TCGA-86-A4JF	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	0.1667
p.S1076T	TCGA-86-A4JF	LUAD	TCGA	LTPDGE	DEG_SCF_FBW7_2	0.1111
p.S1094L	TCGA-AP-A0LM	UCEC	TCGA	LTPDGE	DEG_SCF_FBW7_2	0.1944
p.S1094L	DO43306	UCEC	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.1944
p.E1098K	TCGA-EB-A85J	SKCM	TCGA	LTPDGE	DEG_SCF_FBW7_2	0.0833
p.G1088D	DO229010	COCA	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.6087
p.G1088D	DO229013	COCA	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.6087
p.G1088D	DO230659	LAML	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.6087
p.G1088D	DO231140	LAML	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.6087
p.G1088S	DO234220	ESAD	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.5882
p.G1088S	DO233030	GACA	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.5882
p.A1094V	DO233764	GACA	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.1944
p.S1075F	DO11854	GBM	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.0833
p.E1076K	DO45317	LUAD	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.1111
p.P1080T	DO52667	MALY	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.2222
p.E1083Q	DO51675	PAAD	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.3056
p.E1092K	DO50297	SKCM	ICGC	LTPDGE	DEG_SCF_FBW7_2	0.25
p.T1095I	SIDM01019	Acute Myeloid Leukemia	GDSC	LTPDGE	DEG_SCF_FBW7_2	0.1667
p.T1095I	ACH-002258	Leukemia	CCLE	LTPDGE	DEG_SCF_FBW7_2	0.1667
p.T1095I	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	LTPDGE	DEG_SCF_FBW7_2	0.1667
p.D1087H	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LTPDGE	DEG_SCF_FBW7_2	0.6577
p.D1087H	ACH-000951	Lung Cancer	CCLE	LTPDGE	DEG_SCF_FBW7_2	0.6577
p.D1087H	NCI-H2342	lung	COSMIC	LTPDGE	DEG_SCF_FBW7_2	0.6577
p.G1080A	CAL-85-1	breast	COSMIC	LTPDGE	DEG_SCF_FBW7_2	0.2222
p.T1089I	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	LTPDGE	DEG_SCF_FBW7_2	0.7078
p.D1081H	NCI-H2342	lung	COSMIC	LTPDGE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPDGE

Degron related mutations and impact score

Drug responses associated with TEX14 mutations

All proteins holding degron of LTPDGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWB6	Inactive serine/threonine-protein kinase TEX14	DEG_SCF_FBW7_2	1084:1089	LTPDGE	FBXW7	0.9686	More...