DegronMD

Uniprot ID: Q9BXM0

Source protein: Periaxin

Source gene: PRX

Class: DEG_APCC_DBOX_1

Location: 1243:1251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.919

ASA_SCORE: 69.2

COIL: 0.6948

CONS_SCORE: 0.8624

DSS_SCORE: 0.4543

HELIX: 0.0344

FCONS_SCORE: 1.0085

RIG_SCORE: 0.7556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1254P	TCGA-68-8251	LUSC	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	0.25
p.A1254P	DO26858	LUSC	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.25
p.A1252T	TCGA-AX-A062	UCEC	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	0.3056
p.A1252T	DO40906	UCEC	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.3056
p.A1252T	ACH-000985	Colon/Colorectal Cancer	CCLE	LRLKLPTLG	DEG_APCC_DBOX_1	0.3056
p.A1233V	TCGA-BR-A4QL	STAD	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	0.0556
p.A1233V	DO38723	STAD	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.0556
p.G1251W	TCGA-EE-A3AA	SKCM	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	0.6714
p.G1251W	DO37571	SKCM	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.6714
p.G1257V	TCGA-G9-6377	PRAD	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	0.1667
p.G1257V	DO36348	PRAD	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.1667
p.A1237T	TCGA-SW-A7EA	STAD	TCGA	LRLKLPTLG	DEG_APCC_DBOX_1	0.1667
p.A1237T	DO51749	STAD	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.1667
p.G1234D	DO222404	BTCA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.0833
p.E1235K	DO233183	GACA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.1111
p.E1235K	SIDM00679	Cervical Carcinoma	GDSC	LRLKLPTLG	DEG_APCC_DBOX_1	0.1111
p.E1235K	ACH-001525	Cervical Cancer	CCLE	LRLKLPTLG	DEG_APCC_DBOX_1	0.1111
p.E1235K	HT-3	cervix	COSMIC	LRLKLPTLG	DEG_APCC_DBOX_1	0.1111
p.G1257E	DO233780	GACA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.1667
p.L1250R	DO228187	LICA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.8428
p.A1252D	DO229015	LICA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.3056
p.A1233E	DO229025	LICA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.0556
p.A1254T	DO232761	PBCA	ICGC	LRLKLPTLG	DEG_APCC_DBOX_1	0.25
p.T1238A	SIDM01611	Endometrial Carcinoma	GDSC	LRLKLPTLG	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXM0	Periaxin	DEG_APCC_DBOX_1	1243:1251	LRLKLPTLG	APC,CDC20,FZR1	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons