DegronMD

Uniprot ID: O75298

Source protein: Reticulon-2

Source gene: RTN2

Class: DEG_APCC_DBOX_1

Location: 140:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7328

ASA_SCORE: 78.4889

COIL: 0.4558

CONS_SCORE: 0.418

DSS_SCORE: 0.5392

HELIX: 0.5191

FCONS_SCORE: 1.0804

RIG_SCORE: 0.7706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R135C	TCGA-AR-A254	BRCA	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	0.1944
p.R135C	DO1286	BRCA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.1944
p.R135C	DO35174	PACA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.1944
p.A130V	TCGA-CM-5861	COAD	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	0.0556
p.A130V	DO7918	COAD	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.0556
p.T154M	TCGA-CU-A5W6	BLCA	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	0.1667
p.R135H	TCGA-D7-A4YV	STAD	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	0.1944
p.R135H	DO47777	STAD	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.1944
p.R135H	ACH-000122	Leukemia	CCLE	LRLRLDHLG	DEG_APCC_DBOX_1	0.1944
p.P132L	TCGA-EE-A2MU	SKCM	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	0.1111
p.P132L	DO37436	SKCM	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.1111
p.G157R	TCGA-VQ-A8E2	STAD	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	0.0833
p.G157R	DO51758	STAD	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.0833
p.G157R	SIDM00581	Glioblastoma	GDSC	LRLRLDHLG	DEG_APCC_DBOX_1	0.0833
p.G157R	ACH-000738	Brain Cancer	CCLE	LRLRLDHLG	DEG_APCC_DBOX_1	0.0833
p.G157R	GB-1	central_nervous_system	COSMIC	LRLRLDHLG	DEG_APCC_DBOX_1	0.0833
p.L140V	DO219726	CESC	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.5654
p.V145M	DO219663	KIRP	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.7208
p.Q153K	DO228948	LICA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.1944
p.S156Y	DO229025	LICA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.1111
p.G147S	DO50284	SKCM	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	0.6993
p.P138L	G-361	skin	COSMIC	LRLRLDHLG	DEG_APCC_DBOX_1	0.2778
p.R151L	ASH-3	thyroid	COSMIC	LRLRLDHLG	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75298	Reticulon-2	DEG_APCC_DBOX_1	140:148	LRLRLDHLG	APC,CDC20,FZR1	0.7328	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons