DegronMD - O75298(RTN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R135C	TCGA-AR-A254	BRCA	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.R135C	DO1286	BRCA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.R135C	DO35174	PACA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.T218A	TCGA-B5-A5OC	UCEC	TCGA	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.0556
p.T218A	DO52405	UCEC	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.0556
p.G217S	TCGA-BH-A0HF	BRCA	TCGA	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.0833
p.G217S	DO1749	BRCA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.0833
p.A130V	TCGA-CM-5861	COAD	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0556
p.A130V	DO7918	COAD	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0556
p.T154M	TCGA-CU-A5W6	BLCA	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1667
p.P205S	TCGA-D3-A1QB	SKCM	TCGA	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation altering degron motif	0.6752
p.P205S	DO47573	SKCM	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation altering degron motif	0.6752
p.Q206K	TCGA-D3-A8GI	SKCM	TCGA	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation altering degron motif	0.5833
p.Q206K	DO50284	SKCM	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation altering degron motif	0.5833
p.R135H	TCGA-D7-A4YV	STAD	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.R135H	DO47777	STAD	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.R135H	ACH-000122	Leukemia	CCLE	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.G210C	TCGA-DS-A0VK	CESC	TCGA	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.2778
p.G210C	DO6256	CESC	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.2778
p.P132L	TCGA-EE-A2MU	SKCM	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1111
p.P132L	DO37436	SKCM	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1111
p.G212W	TCGA-ER-A195	SKCM	TCGA	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.2222
p.E201K	TCGA-G4-6586	COAD	TCGA	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.3056
p.E201K	DO9698	COAD	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.3056
p.G157R	TCGA-VQ-A8E2	STAD	TCGA	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.G157R	DO51758	STAD	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.G157R	SIDM00581	Glioblastoma	GDSC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.G157R	ACH-000738	Brain Cancer	CCLE	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.G157R	GB-1	central nervous system	COSMIC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.L140V	DO219726	CESC	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.5654
p.T195N	DO219917	DLBC	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.1389
p.P218T	DO220562	KICH	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.0556
p.V145M	DO219663	KIRP	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.7208
p.Q153K	DO228948	LICA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.S156Y	DO229025	LICA	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1111
p.S198P	DO229056	LICA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation blocking phosphorylation signal	0.6667
p.A199D	DO229009	LICA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation blocking phosphorylation signal	0.6944
p.Y192H	DO44802	LICA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.0556
p.T195I	DO220885	MELA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.1389
p.G147S	DO50284	SKCM	ICGC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.6993
p.P209L	SIDM00238	Ovarian Carcinoma	GDSC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.3056
p.P209L	ACH-000947	Ovarian Cancer	CCLE	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.3056
p.P209L	OVK-18	ovary	COSMIC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.3056
p.P138L	G-361	skin	COSMIC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.2778
p.R151L	ASH-3	thyroid	COSMIC	LRLRLDHLG	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.25
p.A196V	NCI-H2172	lung	COSMIC	VLTPQLS	DEG_SCF_FBW7_1	202:208	Mutation rewiring degron network	0.1667

Kaplan plot for RTN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTN2

UniProt ID: O75298

Entrez ID: 6253

Protein name: Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RTN2 in