DegronMD

Uniprot ID: O75298

Source protein: Reticulon-2

Source gene: RTN2

Class: DEG_SCF_FBW7_1

Location: 202:208

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 77.9143

COIL: 0.8791

CONS_SCORE: 0.4305

DSS_SCORE: 0.8262

HELIX: 0.0337

FCONS_SCORE: 1.1048

RIG_SCORE: 0.627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T218A	TCGA-B5-A5OC	UCEC	TCGA	VLTPQLS	DEG_SCF_FBW7_1	0.0556
p.T218A	DO52405	UCEC	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.0556
p.G217S	TCGA-BH-A0HF	BRCA	TCGA	VLTPQLS	DEG_SCF_FBW7_1	0.0833
p.G217S	DO1749	BRCA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.0833
p.P205S	TCGA-D3-A1QB	SKCM	TCGA	VLTPQLS	DEG_SCF_FBW7_1	0.6752
p.P205S	DO47573	SKCM	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.6752
p.Q206K	TCGA-D3-A8GI	SKCM	TCGA	VLTPQLS	DEG_SCF_FBW7_1	0.5833
p.Q206K	DO50284	SKCM	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.5833
p.G210C	TCGA-DS-A0VK	CESC	TCGA	VLTPQLS	DEG_SCF_FBW7_1	0.2778
p.G210C	DO6256	CESC	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.2778
p.G212W	TCGA-ER-A195	SKCM	TCGA	VLTPQLS	DEG_SCF_FBW7_1	0.2222
p.E201K	TCGA-G4-6586	COAD	TCGA	VLTPQLS	DEG_SCF_FBW7_1	0.3056
p.E201K	DO9698	COAD	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.3056
p.T195N	DO219917	DLBC	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.1389
p.P218T	DO220562	KICH	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.0556
p.S198P	DO229056	LICA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.6667
p.A199D	DO229009	LICA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.6944
p.Y192H	DO44802	LICA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.0556
p.T195I	DO220885	MELA	ICGC	VLTPQLS	DEG_SCF_FBW7_1	0.1389
p.P209L	SIDM00238	Ovarian Carcinoma	GDSC	VLTPQLS	DEG_SCF_FBW7_1	0.3056
p.P209L	ACH-000947	Ovarian Cancer	CCLE	VLTPQLS	DEG_SCF_FBW7_1	0.3056
p.P209L	OVK-18	ovary	COSMIC	VLTPQLS	DEG_SCF_FBW7_1	0.3056
p.A196V	NCI-H2172	lung	COSMIC	VLTPQLS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75298	Reticulon-2	DEG_SCF_FBW7_1	202:208	VLTPQLS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons