DegronMD

Uniprot ID: P23769

Source protein: Endothelial transcription factor GATA-2

Source gene: GATA2

Class: DEG_APCC_DBOX_1

Location: 229:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9796

ASA_SCORE: 44.6889

COIL: 0.802

CONS_SCORE: 0.3243

DSS_SCORE: 0.6334

HELIX: 0.1198

FCONS_SCORE: 1.0251

RIG_SCORE: 0.6397

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R230C	TCGA-BR-A4QL	STAD	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.8301
p.R230C	DO38723	STAD	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.8301
p.M236I	TCGA-EE-A20C	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.6507
p.M236I	DO47665	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.6507
p.E219D	TCGA-EE-A2MD	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.0556
p.E219D	DO37851	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.0556
p.P247A	TCGA-ER-A3EV	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.0556
p.P247A	DO48597	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.0556
p.E224K	TCGA-FI-A2D0	UCEC	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.1944
p.E224K	DO43891	UCEC	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.1944
p.T238I	TCGA-FS-A4FC	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.T238I	DO37762	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.G237V	TCGA-JY-A6FH	ESCA	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.6421
p.H243Y	TCGA-VQ-A8P2	STAD	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.1667
p.H243Y	DO51761	STAD	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.1667
p.S227N	SIDM01117	Small Cell Lung Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.2778
p.S227N	ACH-002176	Lung Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.2778
p.S227N	NCI-H748	lung	COSMIC	LRPGLATMG	DEG_APCC_DBOX_1	0.2778
p.M236T	SIDM01878	Non-Cancerous	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.7423
p.M236T	SIDM00053	Pancreatic Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.7423
p.M236T	ACH-002360	Non-Cancerous	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.7423
p.P228L	SIDM00417	Plasma Cell Myeloma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.P228L	ACH-000626	Myeloma	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.P228L	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.L229R	SIDM01770	Gastric Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.7316
p.L229R	ACH-000908	Gastric Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.7316
p.P240S	ACH-000930	Breast Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRPGLATMG

Degron related mutations and impact score

Drug responses associated with GATA2 mutations

All proteins holding degron of LRPGLATMG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23769	Endothelial transcription factor GATA-2	DEG_APCC_DBOX_1	229:237	LRPGLATMG	APC,CDC20,FZR1	0.9796	More...