DegronMD

Uniprot ID: P23769

Source protein: Endothelial transcription factor GATA-2

Source gene: GATA2

Class: DEG_APCC_DBOX_1

Location: 229:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9796

ASA_SCORE: 44.6889

COIL: 0.802

CONS_SCORE: 0.3243

DSS_SCORE: 0.6334

HELIX: 0.1198

FCONS_SCORE: 1.0251

RIG_SCORE: 0.6397

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R230C	TCGA-BR-A4QL	STAD	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.8301
p.R230C	DO38723	STAD	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.8301
p.M236T	SIDM01878	Non-Cancerous	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.7423
p.M236T	SIDM00053	Pancreatic Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.7423
p.M236T	ACH-002360	Non-Cancerous	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.7423
p.L229R	SIDM01770	Gastric Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.7316
p.L229R	ACH-000908	Gastric Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.7316
p.M236I	TCGA-EE-A20C	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.6507
p.M236I	DO47665	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.6507
p.G237V	TCGA-JY-A6FH	ESCA	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.6421
p.T238I	TCGA-FS-A4FC	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.T238I	DO37762	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.P228L	SIDM00417	Plasma Cell Myeloma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.P228L	ACH-000626	Myeloma	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.P228L	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	LRPGLATMG	DEG_APCC_DBOX_1	0.3056
p.S227N	SIDM01117	Small Cell Lung Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	0.2778
p.S227N	ACH-002176	Lung Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.2778
p.S227N	NCI-H748	lung	COSMIC	LRPGLATMG	DEG_APCC_DBOX_1	0.2778
p.P240S	ACH-000930	Breast Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	0.25
p.E224K	TCGA-FI-A2D0	UCEC	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.1944
p.E224K	DO43891	UCEC	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.1944
p.H243Y	TCGA-VQ-A8P2	STAD	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.1667
p.H243Y	DO51761	STAD	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.1667
p.E219D	TCGA-EE-A2MD	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	0.0556
p.E219D	DO37851	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	0.0556

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Drug responses associated with GATA2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRPGLATMG

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23769	Endothelial transcription factor GATA-2	DEG_APCC_DBOX_1	229:237	LRPGLATMG	APC,CDC20,FZR1	0.9796	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRPGLATMG

Degron related mutations and impact score

Drug responses associated with GATA2 mutations

All proteins holding degron of LRPGLATMG