DegronMD - P23769(GATA2)

GO - Biological processes (BP): cell differentiation in hindbrain [GO:0021533]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; central nervous system neuron development [GO:0021954]; cochlea development [GO:0090102]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; definitive hemopoiesis [GO:0060216]; embryonic placenta development [GO:0001892]; eosinophil fate commitment [GO:0035854]; GABAergic neuron differentiation [GO:0097154]; homeostasis of number of cells within a tissue [GO:0048873]; inner ear morphogenesis [GO:0042472]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; pituitary gland development [GO:0021983]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of forebrain neuron differentiation [GO:2000977]; regulation of histone acetylation [GO:0035065]; regulation of primitive erythrocyte differentiation [GO:0010725]; response to lipid [GO:0033993]; semicircular canal development [GO:0060872]; somatic stem cell population maintenance [GO:0035019]; urogenital system development [GO:0001655]; vascular wound healing [GO:0061042]; ventral spinal cord interneuron differentiation [GO:0021514] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S192F	TCGA-46-3769	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	193:197	Mutation blocking phosphorylation signal	0.75
p.S192F	DO26590	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	193:197	Mutation blocking phosphorylation signal	0.75
p.R230C	TCGA-BR-A4QL	STAD	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.8301
p.R230C	DO38723	STAD	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.8301
p.P177S	TCGA-CM-6170	COAD	TCGA	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation altering degron motif	0.6752
p.P177S	DO7849	COAD	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation altering degron motif	0.6752
p.M236I	TCGA-EE-A20C	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6507
p.M236I	DO47665	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6507
p.E219D	TCGA-EE-A2MD	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.0556
p.E219D	DO37851	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.0556
p.P175L	TCGA-EE-A2MJ	SKCM	TCGA	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation altering degron motif	0.6471
p.P175L	DO38099	SKCM	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation altering degron motif	0.6471
p.P247A	TCGA-ER-A3EV	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.0556
p.P247A	DO48597	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.0556
p.E224K	TCGA-FI-A2D0	UCEC	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1944
p.E224K	DO43891	UCEC	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1944
p.T238I	TCGA-FS-A4FC	SKCM	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.T238I	DO37762	SKCM	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.P183H	TCGA-GN-A265	SKCM	TCGA	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.25
p.P183H	TCGA-GN-A265	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.P183H	DO37491	SKCM	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.25
p.P183H	DO37491	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.G237V	TCGA-JY-A6FH	ESCA	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6421
p.H243Y	TCGA-VQ-A8P2	STAD	TCGA	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1667
p.H243Y	DO51761	STAD	ICGC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1667
p.A164T	DO228483	BRCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.A164T	DO229010	COCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.A164T	DO229013	COCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.A164T	DO229003	COCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.A164T	DO229346	LAML	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.A164T	DO228941	LICA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.A164T	DO230937	LUSC	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.A164T	DO231102	LUSC	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.0556
p.G200D	DO222626	BTCA	ICGC	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.T176M	DO233088	GACA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation altering degron motif	0.8534
p.S168F	DO222420	MELA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.1667
p.S166C	DO46330	OV	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.1111
p.D207G	DO230523	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.P175S	DO229467	SKCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation altering degron motif	0.5641
p.S227N	SIDM01117	Small Cell Lung Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.2778
p.S227N	ACH-002176	Lung Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.2778
p.S227N	NCI-H748	lung	COSMIC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.2778
p.M236T	SIDM01878	Non-Cancerous	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7423
p.M236T	SIDM00053	Pancreatic Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7423
p.M236T	ACH-002360	Non-Cancerous	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7423
p.P228L	SIDM00417	Plasma Cell Myeloma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.P228L	ACH-000626	Myeloma	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.P228L	U-266	haematopoietic and lymphoid tissue	COSMIC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.A198V	SIDM00217	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.A198V	ACH-000999	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.A198V	SNU-1040	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.L229R	SIDM01770	Gastric Carcinoma	GDSC	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7316
p.L229R	ACH-000908	Gastric Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7316
p.A198T	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.A198T	ACH-000925	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.G167S	SIDM00959	Acute Myeloid Leukemia	GDSC	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.1389
p.G167S	ACH-000641	Leukemia	CCLE	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.1389
p.G167S	ACH-001036	Leukemia	CCLE	PPTPPKE	DEG_SCF_FBW7_2	174:180	Mutation rewiring degron network	0.1389
p.A203T	ACH-000870	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.P240S	ACH-000930	Breast Cancer	CCLE	LRPGLATMG	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.25

Kaplan plot for GATA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GATA2

UniProt ID: P23769

Entrez ID: 2624

Protein name: Endothelial transcription factor GATA-2 (GATA-binding protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GATA2 in