DegronMD

Uniprot ID: P23769

Source protein: Endothelial transcription factor GATA-2

Source gene: GATA2

Class: DEG_SCF_FBW7_2

Location: 174:180

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 69.1571

COIL: 0.9339

CONS_SCORE: 0.4522

DSS_SCORE: 0.6999

HELIX: 0.03

FCONS_SCORE: 1.3094

RIG_SCORE: 0.5988

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P177S	TCGA-CM-6170	COAD	TCGA	PPTPPKE	DEG_SCF_FBW7_2	0.6752
p.P177S	DO7849	COAD	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.6752
p.P175L	TCGA-EE-A2MJ	SKCM	TCGA	PPTPPKE	DEG_SCF_FBW7_2	0.6471
p.P175L	DO38099	SKCM	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.6471
p.P183H	TCGA-GN-A265	SKCM	TCGA	PPTPPKE	DEG_SCF_FBW7_2	0.25
p.P183H	DO37491	SKCM	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.25
p.A164T	DO228483	BRCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.A164T	DO229010	COCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.A164T	DO229013	COCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.A164T	DO229003	COCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.A164T	DO229346	LAML	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.A164T	DO228941	LICA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.A164T	DO230937	LUSC	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.A164T	DO231102	LUSC	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.0556
p.T176M	DO233088	GACA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.8534
p.S168F	DO222420	MELA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.1667
p.S166C	DO46330	OV	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.1111
p.P175S	DO229467	SKCA	ICGC	PPTPPKE	DEG_SCF_FBW7_2	0.5641
p.G167S	SIDM00959	Acute Myeloid Leukemia	GDSC	PPTPPKE	DEG_SCF_FBW7_2	0.1389
p.G167S	ACH-000641	Leukemia	CCLE	PPTPPKE	DEG_SCF_FBW7_2	0.1389
p.G167S	ACH-001036	Leukemia	CCLE	PPTPPKE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23769	Endothelial transcription factor GATA-2	DEG_SCF_FBW7_2	174:180	PPTPPKE	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons