DegronMD

Uniprot ID: O95865

Source protein: N

Source gene: DDAH2

Class: DEG_APCC_DBOX_1

Location: 223:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8397

ASA_SCORE: 31.6889

COIL: 0.8489

CONS_SCORE: 0.5225

DSS_SCORE: 0.1761

HELIX: 0.0293

FCONS_SCORE: 0.8633

RIG_SCORE: 0.7218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G238V	TCGA-A6-2686	COAD	TCGA	LRPGLPGVP	DEG_APCC_DBOX_1	0.1389
p.G238V	DO7828	COAD	ICGC	LRPGLPGVP	DEG_APCC_DBOX_1	0.1389
p.A216T	TCGA-B5-A3FC	UCEC	TCGA	LRPGLPGVP	DEG_APCC_DBOX_1	0.1389
p.A216T	DO41871	UCEC	ICGC	LRPGLPGVP	DEG_APCC_DBOX_1	0.1389
p.L223F	TCGA-FD-A43N	BLCA	TCGA	LRPGLPGVP	DEG_APCC_DBOX_1	0.587
p.L223F	DO502	BLCA	ICGC	LRPGLPGVP	DEG_APCC_DBOX_1	0.587
p.C220S	TCGA-G3-A5SJ	LIHC	TCGA	LRPGLPGVP	DEG_APCC_DBOX_1	0.25
p.C220S	DO44938	LIHC	ICGC	LRPGLPGVP	DEG_APCC_DBOX_1	0.25
p.G239V	DO225352	BRCA	ICGC	LRPGLPGVP	DEG_APCC_DBOX_1	0.1111
p.D215G	DO232623	PBCA	ICGC	LRPGLPGVP	DEG_APCC_DBOX_1	0.1111
p.R224C	SIDM00938	Breast Carcinoma	GDSC	LRPGLPGVP	DEG_APCC_DBOX_1	0.8301
p.D215N	SIDM00381	Cervical Carcinoma	GDSC	LRPGLPGVP	DEG_APCC_DBOX_1	0.1111
p.D215N	ACH-002020	Cervical Cancer	CCLE	LRPGLPGVP	DEG_APCC_DBOX_1	0.1111
p.D215N	SKG-IIIa	cervix	COSMIC	LRPGLPGVP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95865	N	DEG_APCC_DBOX_1	223:231	LRPGLPGVP	APC,CDC20,FZR1	0.8397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons