DegronMD

Uniprot ID: Q96N95

Source protein: Zinc finger protein 396

Source gene: ZNF396

Class: LIG_APCC_ABBA_1

Location: 184:189

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6967

ASA_SCORE: 100.7333

COIL: 0.792

CONS_SCORE: 0.5187

DSS_SCORE: 0.4914

HELIX: 0.1462

FCONS_SCORE: 0.9225

RIG_SCORE: 0.7124

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S198Y	TCGA-5C-AAPD	LIHC	TCGA	LRPHDE	LIG_APCC_ABBA_1	0.0833
p.S198Y	DO52168	LIHC	ICGC	LRPHDE	LIG_APCC_ABBA_1	0.0833
p.D190V	TCGA-AX-A1CE	UCEC	TCGA	LRPHDE	LIG_APCC_ABBA_1	0.3056
p.D190V	DO42280	UCEC	ICGC	LRPHDE	LIG_APCC_ABBA_1	0.3056
p.S183Y	DO229031	LICA	ICGC	LRPHDE	LIG_APCC_ABBA_1	0.3056
p.P186L	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	LRPHDE	LIG_APCC_ABBA_1	0.6471
p.P186L	ACH-000481	Lung Cancer	CCLE	LRPHDE	LIG_APCC_ABBA_1	0.6471
p.P186L	NCI-H2170	lung	COSMIC	LRPHDE	LIG_APCC_ABBA_1	0.6471
p.P186S	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRPHDE	LIG_APCC_ABBA_1	0.6752
p.P186S	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	LRPHDE	LIG_APCC_ABBA_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N95	Zinc finger protein 396	LIG_APCC_ABBA_1	184:189	LRPHDE	APC,CDC20,FZR1	0.6967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons