DegronMD

Uniprot ID: Q8N9N2

Source protein: Activating signal cointegrator 1 complex subunit 1

Source gene: ASCC1

Class: DEG_APCC_DBOX_1

Location: 4:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6028

ASA_SCORE: 70.4111

COIL: 0.4851

CONS_SCORE: 0.4772

DSS_SCORE: 0.5194

HELIX: 0.0039

FCONS_SCORE: 0.9796

RIG_SCORE: 0.8118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5H	TCGA-B5-A11E	UCEC	TCGA	LRPQLIRID	DEG_APCC_DBOX_1	0.8244
p.R5H	TCGA-CM-4743	COAD	TCGA	LRPQLIRID	DEG_APCC_DBOX_1	0.8244
p.R5H	DO8103	COAD	ICGC	LRPQLIRID	DEG_APCC_DBOX_1	0.8244
p.R5H	DO41644	UCEC	ICGC	LRPQLIRID	DEG_APCC_DBOX_1	0.8244
p.P20Q	TCGA-D3-A2JC	SKCM	TCGA	LRPQLIRID	DEG_APCC_DBOX_1	0.1111
p.P20Q	DO233864	GACA	ICGC	LRPQLIRID	DEG_APCC_DBOX_1	0.1111
p.P20Q	DO47578	SKCM	ICGC	LRPQLIRID	DEG_APCC_DBOX_1	0.1111
p.R10I	DO222884	COCA	ICGC	LRPQLIRID	DEG_APCC_DBOX_1	0.6991
p.Q22K	DO229015	LICA	ICGC	LRPQLIRID	DEG_APCC_DBOX_1	0.0556
p.V3A	SIDM00087	Plasma Cell Myeloma	GDSC	LRPQLIRID	DEG_APCC_DBOX_1	0.3056
p.L4V	SIDM00476	Ovarian Carcinoma	GDSC	LRPQLIRID	DEG_APCC_DBOX_1	0.5654
p.L4V	ACH-001373	Ovarian Cancer	CCLE	LRPQLIRID	DEG_APCC_DBOX_1	0.5654
p.L4V	OV-17R	ovary	COSMIC	LRPQLIRID	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9N2	Activating signal cointegrator 1 complex subunit 1	DEG_APCC_DBOX_1	4:12	LRPQLIRID	APC,CDC20,FZR1	0.6028	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons