DegronMD

Uniprot ID: Q5KU26

Source protein: Collectin-12

Source gene: COLEC12

Class: DEG_APCC_DBOX_1

Location: 118:126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8488

ASA_SCORE: 77.6

COIL: 0.0276

CONS_SCORE: 0.4408

DSS_SCORE: 0.3791

HELIX: 0.9723

FCONS_SCORE: 1.0088

RIG_SCORE: 0.8032

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T135M	TCGA-2H-A9GF	ESCA	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.0833
p.T135M	TCGA-AP-A051	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.0833
p.T135M	TCGA-C5-A8XI	CESC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.0833
p.T135M	DO49900	CESC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.0833
p.T135M	DO234161	ESAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.0833
p.T135M	DO42673	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.0833
p.I115T	TCGA-97-8177	LUAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.25
p.I115T	DO23600	LUAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.25
p.K131N	TCGA-A5-A0G1	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.3056
p.K131N	DO42472	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.3056
p.T129N	TCGA-AX-A05Z	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.25
p.T129N	TCGA-AX-A1CE	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.25
p.T129N	DO40884	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.25
p.T129N	DO42280	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.25
p.I125L	TCGA-B5-A11E	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.6063
p.I125L	DO41644	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.6063
p.R123C	TCGA-B5-A11E	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	TCGA-D3-A51J	SKCM	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	TCGA-DM-A1HB	COAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	TCGA-F5-6814	READ	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	DO220877	MELA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	DO222904	MELA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	DO36556	READ	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	DO47359	SKCM	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	DO41644	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	SIDM00193	Colorectal Carcinoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	ACH-000991	Colon/Colorectal Cancer	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R123C	SNU-81	large_intestine	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	0.719
p.R119C	TCGA-CG-5723	STAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.8301
p.R119C	DO38376	STAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.8301
p.L118I	TCGA-VQ-A91D	STAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	0.6063
p.L118I	DO51783	STAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.6063
p.R112T	DO222650	BTCA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.1667
p.N132K	DO229009	LICA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.1667
p.L108F	DO219877	SKCA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	0.0556
p.L108F	SIDM00516	Melanoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	0.0556
p.L108F	ACH-002166	Skin Cancer	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	0.0556
p.L108F	MZ7-mel	skin	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	0.0556
p.R119H	SIDM00040	Gastric Carcinoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	0.8244
p.R119H	TMK-1	stomach	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	0.8244
p.E124K	SIDM00844	Burkitt's Lymphoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	0.591
p.E124K	ACH-000654	Lymphoma	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	0.591
p.E124K	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	0.591
p.E124D	SIDM01588	Endometrial Carcinoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	0.5647
p.E124D	ACH-000993	Endometrial/Uterine Cancer	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	0.5647

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRQQLREIT

Degron related mutations and impact score

Drug responses associated with COLEC12 mutations

All proteins holding degron of LRQQLREIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5KU26	Collectin-12	DEG_APCC_DBOX_1	118:126	LRQQLREIT	APC,CDC20,FZR1	0.8488	More...