DegronMD - Q5KU26(COLEC12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T135M	TCGA-2H-A9GF	ESCA	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.T135M	TCGA-AP-A051	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.T135M	TCGA-C5-A8XI	CESC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.T135M	DO49900	CESC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.T135M	DO234161	ESAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.T135M	DO42673	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.P608T	TCGA-94-A5I4	LUSC	TCGA	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.1944
p.P608T	DO219175	LUSC	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.1944
p.I115T	TCGA-97-8177	LUAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.I115T	DO23600	LUAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.K131N	TCGA-A5-A0G1	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation substituting flanking lysine	0.3056
p.K131N	DO42472	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation substituting flanking lysine	0.3056
p.D604G	TCGA-A5-A7WK	UCEC	TCGA	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.3056
p.D604G	DO223279	UCEC	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.3056
p.P591L	TCGA-AA-3524	COAD	TCGA	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.1389
p.P591L	DO8011	COAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.1389
p.T129N	TCGA-AX-A05Z	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.T129N	TCGA-AX-A1CE	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.T129N	DO40884	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.T129N	DO42280	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.I125L	TCGA-B5-A11E	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6063
p.I125L	DO41644	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6063
p.R123C	TCGA-B5-A11E	UCEC	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	TCGA-D3-A51J	SKCM	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	TCGA-DM-A1HB	COAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	TCGA-F5-6814	READ	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	DO220877	MELA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	DO222904	MELA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	DO36556	READ	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	DO47359	SKCM	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	DO41644	UCEC	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	SIDM00193	Colorectal Carcinoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	ACH-000991	Colon/Colorectal Cancer	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R123C	SNU-81	large intestine	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.719
p.R119C	TCGA-CG-5723	STAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.8301
p.R119C	DO38376	STAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.8301
p.P600Q	TCGA-DA-A1I5	SKCM	TCGA	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.7035
p.P600Q	DO37447	SKCM	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.7035
p.P600Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.7035
p.P600Q	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.7035
p.L118I	TCGA-VQ-A91D	STAD	TCGA	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6063
p.L118I	DO51783	STAD	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6063
p.R112T	DO222650	BTCA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.1667
p.G606S	DO229010	COCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO229013	COCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO229016	COCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO234204	ESAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO234285	ESAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO230659	LAML	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO228941	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO229047	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.G606S	DO230990	LUSC	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.25
p.N605S	DO228971	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.2778
p.P598T	DO229009	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.7031
p.N132K	DO229009	LICA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.1667
p.E603K	DO232761	PBCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.7022
p.L108F	DO219877	SKCA	ICGC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.L108F	SIDM00516	Melanoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.L108F	ACH-002166	Skin Cancer	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.L108F	MZ7-mel	skin	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.D604H	SIDM00969	Ovarian Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.3056
p.R119H	SIDM00040	Gastric Carcinoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.8244
p.R119H	TMK-1	stomach	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.8244
p.E124K	SIDM00844	Burkitt's Lymphoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.591
p.E124K	ACH-000654	Lymphoma	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.591
p.E124K	Raji	haematopoietic and lymphoid tissue	COSMIC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.591
p.P600L	SIDM00839	Colorectal Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.7582
p.P602L	SIDM01770	Gastric Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation altering degron motif	0.6471
p.E124D	SIDM01588	Endometrial Carcinoma	GDSC	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.5647
p.E124D	ACH-000993	Endometrial/Uterine Cancer	CCLE	LRQQLREIT	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.5647
p.P591S	ACH-001554	Eye Cancer	CCLE	PTPAPE	DEG_SCF_FBW7_2	598:603	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COLEC12

UniProt ID: Q5KU26

Entrez ID: 81035

Protein name: Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COLEC12 in