DegronMD

Uniprot ID: Q5KU26

Source protein: Collectin-12

Source gene: COLEC12

Class: DEG_SCF_FBW7_2

Location: 598:603

E3 ligase: FBXW7

DEGRON score: 0.9614

ASA_SCORE: 72.9333

COIL: 0.8895

CONS_SCORE: 0.2922

DSS_SCORE: 0.6343

HELIX: 0.0592

FCONS_SCORE: 0.6811

RIG_SCORE: 0.6248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P608T	TCGA-94-A5I4	LUSC	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.1944
p.P608T	DO219175	LUSC	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.1944
p.D604G	TCGA-A5-A7WK	UCEC	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.3056
p.D604G	DO223279	UCEC	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.3056
p.P591L	TCGA-AA-3524	COAD	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.1389
p.P591L	DO8011	COAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.1389
p.P600Q	TCGA-DA-A1I5	SKCM	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.7035
p.P600Q	DO37447	SKCM	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.7035
p.P600Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PTPAPE	DEG_SCF_FBW7_2	0.7035
p.P600Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAPE	DEG_SCF_FBW7_2	0.7035
p.G606S	DO229010	COCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO229013	COCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO229016	COCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO234204	ESAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO234285	ESAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO230659	LAML	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO228941	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO229047	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.G606S	DO230990	LUSC	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.N605S	DO228971	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.2778
p.P598T	DO229009	LICA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.7031
p.E603K	DO232761	PBCA	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.7022
p.D604H	SIDM00969	Ovarian Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	0.3056
p.P600L	SIDM00839	Colorectal Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	0.7582
p.P602L	SIDM01770	Gastric Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	0.6471
p.P591S	ACH-001554	Eye Cancer	CCLE	PTPAPE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46379	Large proline-rich protein BAG6	DEG_SCF_FBW7_2	259:264	PTPAPE	FBXW7	0.8992	More...
Q5KU26	Collectin-12	DEG_SCF_FBW7_2	598:603	PTPAPE	FBXW7	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons