DegronMD

Uniprot ID: P46379

Source protein: Large proline-rich protein BAG6

Source gene: BAG6

Class: DEG_SCF_FBW7_2

Location: 259:264

E3 ligase: FBXW7

DEGRON score: 0.8992

ASA_SCORE: 92.3

COIL: 0.9442

CONS_SCORE: 0.3327

DSS_SCORE: 0.8645

HELIX: 0.0315

FCONS_SCORE: 0.8054

RIG_SCORE: 0.5001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A257T	TCGA-B0-5098	KIRC	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.2778
p.P273H	TCGA-B5-A1MX	UCEC	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.0833
p.P273H	TCGA-DF-A2KN	UCEC	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.0833
p.H270N	TCGA-X9-A973	SARC	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.1667
p.P271H	TCGA-XK-AAIW	PRAD	TCGA	PTPAPE	DEG_SCF_FBW7_2	0.1389
p.E272K	DO8264	COAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.1111
p.A251T	DO18938	KIRC	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.5556
p.A256S	DO51079	PRAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.P265H	DO51407	PRAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.3056
p.H264N	DO220329	SARC	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.7423
p.L274P	DO38819	STAD	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.0556
p.P267H	DO223282	UCEC	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.P267H	DO41999	UCEC	ICGC	PTPAPE	DEG_SCF_FBW7_2	0.25
p.A274V	SIDM01117	Small Cell Lung Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	0.0556
p.L250F	SIDM00596	Endometrial Carcinoma	GDSC	PTPAPE	DEG_SCF_FBW7_2	0.0833
p.L250F	HEC-1	endometrium	COSMIC	PTPAPE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46379	Large proline-rich protein BAG6	DEG_SCF_FBW7_2	259:264	PTPAPE	FBXW7	0.8992	More...
Q5KU26	Collectin-12	DEG_SCF_FBW7_2	598:603	PTPAPE	FBXW7	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons