DegronMD

Uniprot ID: P06727

Source protein: Apolipoprotein A-IV

Source gene: APOA4

Class: DEG_APCC_DBOX_1

Location: 263:271

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7038

ASA_SCORE: 60.3556

COIL: 0.0623

CONS_SCORE: 0.8525

DSS_SCORE: 0.3997

HELIX: 0.9386

FCONS_SCORE: 1.0381

RIG_SCORE: 0.7651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A271D	TCGA-44-8120	LUAD	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	0.6682
p.A271D	DO45402	LUAD	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.6682
p.A258T	TCGA-AX-A2HC	UCEC	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	0.1944
p.A258T	DO41572	UCEC	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.1944
p.L278P	TCGA-AZ-6601	COAD	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	0.1389
p.L278P	DO8119	COAD	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.1389
p.A258G	TCGA-ZP-A9CZ	LIHC	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	0.1944
p.A258G	DO52330	LIHC	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.1944
p.R264L	DO225081	BRCA	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.8428
p.R264L	DO52559	BRCA	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.8428
p.E272K	DO229177	LMS	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.3056
p.R275C	DO33091	PACA	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.2222
p.A254T	DO232899	PEME	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	0.0833
p.K253N	SIDM00583	Pancreatic Carcinoma	GDSC	LRQRLAPLA	DEG_APCC_DBOX_1	0.1667
p.K253N	ACH-001107	Pancreatic Cancer	CCLE	LRQRLAPLA	DEG_APCC_DBOX_1	0.1667
p.K253N	KP-1N	pancreas	COSMIC	LRQRLAPLA	DEG_APCC_DBOX_1	0.1667
p.R264W	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRQRLAPLA	DEG_APCC_DBOX_1	0.8634
p.R264W	CRO-AP3	NS	COSMIC	LRQRLAPLA	DEG_APCC_DBOX_1	0.8634
p.G280V	SIDM00685	Glioblastoma	GDSC	LRQRLAPLA	DEG_APCC_DBOX_1	0.0833
p.G280V	ACH-000819	Brain Cancer	CCLE	LRQRLAPLA	DEG_APCC_DBOX_1	0.0833
p.G280V	LN-18	central_nervous_system	COSMIC	LRQRLAPLA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06727	Apolipoprotein A-IV	DEG_APCC_DBOX_1	263:271	LRQRLAPLA	APC,CDC20,FZR1	0.7038	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons