DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRRFLSSVE
Uniprot ID:
Q8N5W9
Source protein:
Refilin-B
Source gene:
RFLNB
Class:
DEG_APCC_DBOX_1
Location:
190:198
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8964
ASA_SCORE:
46.6222
COIL:
0.1323
CONS_SCORE:
0.8389
DSS_SCORE:
0.1907
HELIX:
0.0172
FCONS_SCORE:
1.4185
RIG_SCORE:
0.8747
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RFLNB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRRFLSSVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N5W9
Refilin-B
DEG_APCC_DBOX_1
190:198
LRRFLSSVE
APC,CDC20,FZR1
0.8964
More...