DegronMD

Uniprot ID: Q86VQ6

Source protein: Thioredoxin reductase 3

Source gene: TXNRD3

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6398

ASA_SCORE: 52.2

COIL: 0.0597

CONS_SCORE: -1000

DSS_SCORE: 0.2731

HELIX: 0.9373

FCONS_SCORE: 1.3751

RIG_SCORE: 0.7871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G73E	DO223732	CESC	ICGC	LRRHLVGLI	DEG_APCC_DBOX_1	0.1667
p.H56Q	DO229028	LICA	ICGC	LRRHLVGLI	DEG_APCC_DBOX_1	0.7582
p.H56Q	DO229035	LICA	ICGC	LRRHLVGLI	DEG_APCC_DBOX_1	0.7582
p.S71L	DO222908	MELA	ICGC	LRRHLVGLI	DEG_APCC_DBOX_1	0.1111
p.S71L	DO41542	UCEC	ICGC	LRRHLVGLI	DEG_APCC_DBOX_1	0.1111
p.G54E	DO220285	SARC	ICGC	LRRHLVGLI	DEG_APCC_DBOX_1	0.3056
p.V62A	DO42713	UCEC	ICGC	LRRHLVGLI	DEG_APCC_DBOX_1	0.6936
p.S72N	SIDM01314	Colorectal Carcinoma	GDSC	LRRHLVGLI	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VQ6	Thioredoxin reductase 3	DEG_APCC_DBOX_1	55:63	LRRHLVGLI	APC,CDC20,FZR1	0.6398	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons